OSAHS Patients With Cardiac Structure Change And Function Disorder And The CPAP Of Severe OSAHS

Objective:The aim of this study was to investigate the changes of cardiac structure and function of OSAHS patients,and the changes of relevant Tei and the serum BNP concentration of severe OSAHS patients who were treated with continuous positive airway pressure treatment after 1 year.We tried to provide theoretical basis for the classification of OSAHS and the treatment effects of CPAP.Results:The Tei of OSAHS patients with disease severity,the increased as below:mild for(0.384 ± 0.07),medium(0.395 ± 0.03,severe(0.401 ± 0.03),and the difference is statistically significant(F = 3.669,P = 3.669).The serum BNP concentration of OSAHS patients with disease severity,the increased as below:mild(8.61 ± 18.65),medium(74.75 ± 16.8),severe(98.77 ±22.74),and the difference is statistically significant(F = 965.684,P = 965.684).Before the CPAP treatment of severe OSAHS patients,the mean Tei of them was(0.401 ± 0.03).And then,after the CPAP treatment of severe OSAHS patients,the mean Tei of them was(0.375±0.02).The difference is statistically significant(P<0.05).Before the CPAP treatment of severe OSAHS patients,the mean serum BNP concentration was(98.77± 22.74),respectively,after the treatment the mean serum BNP concentration was(40.26 ±12.28).And the difference is statistically significant(P<0.05).The mean Tei of severe OSAHS patients,who had been treated with CPAP therapy after 1 years was(0.375 ±0.02),respectively who had not been treated with CPAP therapy after 1 years was(0.498 ± 0.12),and the difference is statistically significant(P<0.05).The mean serum BNP level of severe patients,who had been treated with CPAP therapy after 1 years was(40.26 ± 12.28),who had not been treated was(121.46 ± 12.56),and the difference is statistically significant(P<0.05).The Tei and serum BNP concentration of severe OSAHS patients were positively correlated with AHI index(r = 0.702,P = 0.000;r = 0.865,P = 0.000).The Tei and serum BNP concentration of severe OSAHS patients were negatively correlated with SpO2(r = 0.503,P = 0.000;r = 0.765,P = 0.000).Conclusion:1.The Tei of OSAHS patients increases with severity of disease,and positively correlated with it;2.The serum BNP concentration of OSAHS patients increases with severity of disease,and positively correlated with it;3.The CPAP treatment of serve OSAHS patients could obviously reduce the Tei and serum BNP concentration.The CPAP treatment is worthy to promote in clinical.