Study On The Expression And Correlation Of VEGF,ET,NO And AT-? In Diabetic Retinopathy

Objective: To investigate the expression and correlation of vascular endothelial growth factor(VEGF),endothelin(ET),nitric oxide(NO)and antithrombin III(AT-III)in diabetic retinopathy.Methods:90 patients with diabetes mellitus admitted to the Department of Ophthalmology and Endocrinology,the First Affiliated Hospital of Medical University from January 2015 to December 2016 were enrolled.Meanwhile,30 healthy people who underwent routine examination in our hospital were selected as normal control group.According to fundus fluorescein angiography,diabetic patients were divided into no retinopathy group(NDR group),non-proliferative retinopathy group(NPDR group)and proliferative retinopathy group(PDR group),and 30 cases were segmented into each group.The efficacy of four groups of VEGF,ET,NO,AT-III and four indexes on diabetic retinopathy(DR)was compared.Results: The diabetic group VEGF,ET and NO were significantly higher than those in control group,NDPR group of patients with AT-III levels were significantly lower than the other three groups,PDR group AT-III level is relatively high compared with the other groups(P<0.05);The sensitivity and specificity of VEGF in diabetic retinopathy test and diagnosis were significantly higher than those of the other three indicators(P<0.05).Conclusion: In the early stage of diabetic retinopathy,the vascular endothelial function has been accordingly changed,the index level of vascular endothelial function is related to the development of the patient's condition.VEGF and ET play an important role in the early diagnosis of diabetic retinopathy and entering into the period of proliferative retinopathy.