Correlation Between Sleep Disorders And Bone Mineral Density And Bone Metabolism Markers In Postmenopausal Women

Objective: Postmenopausal osteoporosis belongs to primary OP,which is mainly related to the decline of estrogen in postmenopausal women.In recent years,studies have found that sleep disorders are associated with the occurrence of postmenopausal osteoporosis.To investigate the relationship between sleep disorders and bone mineral density and markers of bone metabolism in postmenopausal women Methods: A total of183 postmenopausal women who met the exclusion criteria from October 2017 to January2019 were enrolled in the PSQI scale and a personal questionnaire.The scores were divided into sleep disorders according to the PSQI score(9-21 points)and non-sleep disorder group(0-8 points),according to the actual sleep time is divided into the group with too little sleep time(less than 6 hours),the normal group of sleep time(6-8 hours),the group with too much sleep time(more than 8 hours)At the same time,bone mineral density and bone metabolism markers were measured Results(1)The bone density of postmenopausal women with sleep disorder was less than that of the non-sleep disorder group(P < 0.01).(2)Postmenopausal women with sleep disorder had higher PINP and CTX score than the non-sleep disorder group(P<0.01).(3)The actual sleep time is less than 6 hours and the sleep time is more than 8 hours.The bone mineral density of postmenopausal women is less than that of postmenopausal women with definite sleep time of 6-8 hours(P<0.01).(4)Actual sleep is actually less than 6 hours compared with actual sleep time.There were no significant differences in bone mineral density between postmenopausal women(P>0.05).(5)The actual sleep time was greater than 8 hours and the actual sleep time was less than 6 hours.Postmenopausal women's bone metabolism markers(PINP and CTX)were more than the actual sleep time.(6)6-8 smallpostmenopausal women with high 6 actual sleep actually less than 6 hours larger than 8hours postmenopausal female bone formation markers no significant difference(P>0.05)(7)actual sleep is actually less than 6 hours larger than 8 hours postmenopausal women High bone resorption markers(P< 0.001)(8)The higher the PSQI score,the lower the bone density Conclusion:(1)The worse the sleep quality of postmenopausal women,the more prone to osteoporosis,and The femoral neck bone density is reduced;the decline in sleep quality may accelerate the bone resorption process.But has less effect on bone formation.(2)Postmenopausal women have too long sleep time(more than 8 hours)or too short sleep time(less than 6 hours).As a risk factor for osteoporosis,if the sleep time is too small,the sleep time may be more affected by the bone resorption process.