The Research On The Experience Of Professor Wang Shouchuan In Treatment Of Recurrent Respiratory Tract Infection In Children Based On Data Mining

Objective:With the help of the technology of Data Mining,the information on clinical records of recurrent respiratory tract infection(RRTI)in children by Professor Wang Shouchuan was collected from outpatient department in order to understand the clinical characteristics in Real World Study(RWS)of RRTI and make the exploration of Professor Wang Shouchuan's clinical experiences.Method:Clinical records of recurrent respiratory tract infection in children treated by Professor Wang shouchuan,dating from October 2017 to October 2018,were collected from outpatient department.The relevant data was inputted into Excel for establishing the medical record database after screening,which was then analyzed through frequency analysis,association rules,clustering analysis and efficacy analysis by using SPSS 20.0 and Clementine software to draw the conclusion.Result:One hundred and forty seven children with recurrent respiratory infection were enrolled in this study.The ratio of boys to girls was 1.37:1,the average age was 4.50±2.18 years old,the average height was 107.38±15.67cm,the average weight was 18.17±6.10kg.The gestational age and birth index were relatively normal.Overall nutritional status was lower than that of the healthy children in the same age,and 84.35%RRTI children suffered from allergic diseases.The age of most children was from one to six years old,and Bronchitis accounted for a large proportion.The single course of this disease was more than one week.Allergic constitution,feeding methods,parental allergy,living conditions,passive smoking,seasonal patterns and antibiotic use were risk factors for recurrent respiratory tract infection.Most children developed respiratory infection due to suffering from cold and infection.The 10 kinds of pathogenesis syndrome included qi deficiency,yang deficiency,yin deficiency,wind phlegm,lung heat,phlegm heat,hidden wind,dyspepsia and damp heat and summer damp.Moreover,the correlation between phlegm heat and qi deficiency,lung heat and qi deficiency was higher.Among the clinical syndromes,there were 97 cases of lung spleen qi deficiency syndrome,16 cases of disharmony between ying and wei syndrome,9 cases of spleen and kidney deficiency syndrome,31 cases of lung spleen yin deficiency syndrome,50 cases of lung spleen qi deficiency and disharmony between ying and wei syndrome,19 cases of lung spleen qi deficiency and spleen and kidney deficiency syndrome,17 cases of lung spleen qi deficiency and lung spleen yin deficiency syndrome,6 cases of disharmony between ying and wei and spleen and kidney deficiency syndrome,7 cases of disharmony between ying and wei and lung spleen yin deficiency syndrome,2 cases of spleen and kidney deficiency and lung spleen yin deficiency,8 cases of lung spleen qi deficiency,disharmony between ying and wei and spleen and kidney deficiency syndrome.4 cases of lung spleen qi deficiency,disharmony between ying and wei and lung spleen yin deficiency.The main clinical syndromes were congestion of throat,sweating,light sleep,sneezing occasionally,cough occasionally,apocleisis,night sweat,nasal itching occasionally.Four diagnosis information included poor complexion,Pale red tongue and thin white fur.Professor Wang Shouchuan's representative formula for the treatment of children with recurrent respiratory tract infection in non-acute infection phase was Jinping Decoction.138 herbals were utilized in 266 prescriptions,counting 3571 times,with an average of 13.42 herbals per prescription.The top 30 frequency herbals were:Fried Atractylodes(86.47%),Calcined Oysters(84.59%),Calcined Keels(84.59%),Windproof(83.83%),Scutellaria(78.57%),Xinyi(60.15%),Polygonum Cuspidatum(45.11%),Mulberry White Skin(42.11%),Poria Cocos(39.10%),Raw Licorice(38.35%),Medicated Leaven(38.35%),Parched Hawthorn Fruit(38.35%),Polygonatum(37.22%),Platycodon(36.09%),Platycodon Root(36.09%),Astragalus(25.19%),Radix Isatidis(23.68%),Danan Star(22.56%),Codonopsis(20.68%),Fritillaria(20.30%),Schisandra(19.55%),Radix Pseudostellariae(19.17%),Tangerine(18.80%),Atractylodes(16.17%),Hundreds(15.41%),Honeysuckle(13.16%),Xanthium(12.41%),Hedgehog(12.41%),Reed(12.03%),Glycyrrhiza uralensis(11.65%)and Guangdilong(11.28%).The cluster analysis reached three categories:Cl:Astragalus,Fried Atractylodes,Windproof,Calcined Keel,Calcined Oyster.C2:Codonopsis Pilosula,Medlar,Polygonatum,Mulberry White Skin,Hundreds,Poria Cocos,Xinyi,Banlangen,Astragalus,Polygonum Cuspidatum,Raw Licorice,Medicated Leaven,Parched Hawthorn Fruit;C3:Radix Pseudostellariae,Atractylodes,Tangerine,Zhejiang Fritillaria,Gallium Starch,Xanthium,Guangdilong,Robinia,Schisandra,Honeysuckle,Reed Root,Licorice.Association rules showed that the correlation between herbals of Astragalus and Licorice,Calcined Keel and Calcined Oyster,Medicated Leaven and Parched Hawthorn Fruit,Fried Atractylodes and Windproof et.al were higher.The correlation among three herbals showed that tonic herbs included Astragalus,Fried Atractylodes and Licorice;hurricane herbs included Windproof;solid sputum herbs included Calcined Keel and Calcined Oyster;heat-clearing herbs included Reed Rhizome and Honeysuckle;anti tussive herb included Stemona Sessilifolia.It demonstrated that Professor Wang Shouchuan's main treatment method of recurrent respiratory tract infection in non-acute infection phase was reinforcing lung to consolidate the exterior and dispelling the wind.The clinical efficacy analysis showed that treatment of recurrent respiratory tract infection had a significant effect on the short-term and long-term course of this disease conducted by Professor Wang Shouchuan.The efficacy of TCM syndrome at the 4th week,12th week and 24th week was statistically different from that before treatment(P<0.05)and the TCM syndrome efficacy at the 24th week was statistically different from the 4th week as well as the 12th week(P<0.05),which demonstrated that it was necessary for children with recurrent respiratory tract infection to take Chinese traditional medicine over a long period.Conclusion:This project enriched the clinical data of repeated respiratory infections by means of Data Mining,and further improved the understanding of general conditions,etiology,pathogenesis,predisposing factors,pathogenesis syndromes,syndromes and medications of this disease.In addition,the close relationship between allergic constitution of chlidren and recurrent respiratory tract infection was discovered during the case collection and data analysis.Professor Wang Shouchuan's clinical experiences in treating recurrent respiratory tract infection in non-acute infection phase could be summarized as reinforcing lung to consolidate the exterior,reconciling yingwei;strengthening the body resistance and dispelling hidden wind;strengthening spleen and stomach,reinforcing and eliminating in combination;prescribing accurately and stopping necessarily;enhancing the body to prevent the disease.