Clinical Characteristics And The Levels Of Interleukin-10,Interleukin-2 Receptor,Interleukin-8 In Children With Food Allergy

Objective To study clinical characteristics and the levels of interleukin-10(IL-10),interleukin-2 receptor(IL-2R)and interleukin-8(IL-8)levels in children with non-Ig E-mediated food allergy and Ig E-mediated food allergy.Methods A total of 52 children with food allergy were selected from Anhui Children's Hospital and were randomly divided into Ig E group(51 cases),and non-Ig E group(78 cases),based on the levels of serum Ig E antibody.In addition,67 healthy children were recruited as the control group.Clinical characteristics(including clinical symptoms,gender,age of onset,feeding pattern,duration of disease,positive history of first-degree relative allergy,etc.),laboratory tests(including blood routine,liver function,serum Ig E antibody,food-specific Ig E antibody,stool routine and occult blood,etc.)and the concentration of IL-10,IL-2R and IL-8 in serum were analyzed and compared.Results 1.There was no statistically significant difference between the non-Ig E group and the Ig E group in terms of gender,age of onset,feeding pattern and positive allergy history of first-degree relatives(P>0.05),but patients in the Ig E group with the duration of disease less than 2 weeks were significantly more than those in the non-ige group(P<0.05),while patients in the non-Ig E group with the duration of disease between 2 weeks and 2 months were significantly more than those in the Ig E group(P<0.001).2.The common allergens in the non-Ig E group were milk,eggs,fish and shrimp,and soy products in sequence,and the common allergens in the Ig E group were eggs,milk,nuts,fish and shrimp in sequence.3.There were significantly more cases of simple bloody stool and abdominal distension/crying in the non-Ig E group than in the Ig E group(P<0.05),and there were significantly more cases of respiratory symptoms and eczema in the Ig E group than in the non-Ig E group(P<0.05).4.The blood white cell count,lymphocyte count,eosinophil count and proportion of eosinophil in children with food allergy(including non-Ig E group and Ig E group)were significantly higher than those in control group(P<0.05).There were no statistically significant of the blood white cell count,lymphocyte count,eosinophil count and proportion of eosinophil between the non-Ig E group and the Ig E group(P>0.05).5.The level of IL-10 in children with food allergy(including non-Ig E group and Ig E group)were significantly lower than that in the control group(P<0.001),while the level of IL-2R in children with food allergy(including non-Ig E group and Ig E group)were significantly higher than those in the control group(P<0.001).The level of IL-10 in the non-Ig E group was significantly lower than that in the Ig E group(P<0.001),while the level of IL-2R in the non-Ig E group was significantly higher than that in the Ig E group(P<0.001).The level of IL-8 in the non-Ig E group was significantly higher than that in the control group and the Ig E group(P<0.001),there was no statistic difference in the levels of IL-8 between the Ig E group and the control group(P>0.05).6.Different intervention schemes can alleviate the clinical symptoms of children with food allergy,and different intervention schemes have no effect on the average days of remission of clinical symptoms(P>0.05).Conclusion Food allergy usually occurs in infants under 12 months of age,and the clinical manifestations of food allergy are diverse and non-specific.Clinical diagnosis mainly depends on the detailed medical history,and blood eosinophil count,serum Ig E antibody and the level of IL-10 and IL-2R will help us to determine whether there is a food allergy.Dietary avoidance is the main treatment for food allergy at present,and there is no significant difference in the remission of food allergy symptoms between different intervention schemes.