The Study On Prognoses Of Infancy Food Allergy And Relationships Between Food Allergy And Intestinal Microflora

PARTⅠTHE FOLLOW-UP OF PROGNOSES OF INFANCY FOOD ALLERGYObjective To investigate the tolerance prognoses of food allergy and study the relationships between food allergy and other allergic diseases.Methods 119 children were followed-up for respiratory allergic diseases and other food allergies from 303 children with positive skin prick test reactions during the infancy from Jan, 2000 to Jun, 2003 in the Department of Primary Child Care, Children's Hospital, Chongqing University of Medical Sciences.The questionnaires were answered by all the parents. The other food allergies and food tolerances were diagnosed by Skin prick test, Elimination test and Open food challenge test. Kaplan-Meier survival curves were used to calculate the cumulative tolerance probability. The predictors of food tolerances and influential factors of other allergic diseases were analyzed by unconditional Logistic regression models. Results The average age of 119 children diagnosed as food allergy was 6.0±2.3 months(2～11.9 months)and 94.1% (112)of children with food allergy were strictly limited to take the food allergens. The data from Kaplan-Meier methods showed that the Cumulative tolerance probabilities of cow's milk and egg were 42%, 31% by 1 year after diagnosis; 63%, 62% by 2 years; 77%, 76% by 2.5 years; 77%, 80% by 3 years, respectively and would be 100% after 4 years. By Logistic regression analysis,our study indicated that the rash sizes of skin prick test reactions to cow's milk and egg (OR=2.535,95%CI:1.159～5.543；OR=2.654,95%CI:1.302～5.410,P<0.05)were predictors for the tolerance to cow's milk and egg at 1 year after diagnoses. After 15.6 months of diagnoses(15.6±6.1 months),10.9% of the children with food allergy presented the sensitization to other foods; About 16.8 months after diagnoses (16.8±8.3months), 3.4％ and 12.6％ of the children suffered from allergic rhinitis and asthma ,respectively. In the unconditional Logistic regression analysis, the long-lasting sensitization to egg(OR= 3.596,95%CI: 1.429～9.045,P<0.05)and the respiratory symptoms (OR=4.235,95%CI: 1.152～15.563,P<0.05)were the risk factors of respiratory allergic diseases (allergic rhinitis and asthma),and the sensitization to egg(OR= 6.109,95%CI: 1.818～20.527,P<0.05)was still one of the risk factors to other food allergies. Conclusions 3/4 of children with egg and cow's milk allergy could tolerate egg or cow's milk by 3 years after diagnoses. The predictors of the tolerance to egg and cow's milk were the rash sizes of skin prick test reactions to egg and cow's milk. 3.4% and 12.6% of children with food allergy during the infancy suffered from allergic rhinitis or asthma, respectively. Moreover, the long-lasting sensitization to egg and/or the respiratory symptoms were the risk factors of other allergic diseases.