Clinical,Endoscopic And Pathological Features Of Infants With Food Allergy And Food Intolerance Related Gastric Diseases

Objective:To analyze the clinical,endoscopic and pathological characteristics of gastric diseases related to food allergy and food intolerance in infants,and to explore the changes of gastric eosinophil number and mast cell number in gastric mucosa in infants with food allergy and food intolerance.Methods:Analysis in September 2016 to December 2018 because of abdominal pain,vomiting,hematemesis,bloody digestive internal medicine for clinical manifestations in jiangxi province children's hospital,101 cases of infants and young children in the hospital,with a food allergy group(specific Ig G antibody,food,food allergen specific Ig E antibody positive)and food intolerance group(specific Ig G antibody positive,food,food allergen specific Ig E antibody negative)for the team,to specific Ig G antibody,food,food allergen specific Ig E antibody were negative for the control group,the analysis of three groups of clinical manifestations,endoscopic and pathological features,Eosinophils(EOS)and mast cells(MCs)in gastric mucosa and their changes in gastric diseases related to food allergy and food intolerance were statistically analyzed.Results:1.All the three groups presented gastritis,duodenal mucosa congestion and edema under gastroscopy,with some accompanied by spot and flake erosion and ulcer,among which 22 cases of gastritis,2 cases of duodenal ulcer,1 case of duodenitis and1 case of esophagitis were found in the food allergy group.In the food intolerance group,there were 59 cases of gastritis,4 cases of duodenal ulcer,7 cases of duodenal globulitis and 3 cases of esophagitis.In the control group,there were 20 cases of gastritis,3 cases of duodenitis and 1 case of esophagitis.All pathological results showed superficial gastritis,among which 2 and 12 cases in the food allergy group and the food intolerance group had EOS counts greater than 20 /HPF,respectively.MCs counts greater than 15 /HPF were 5 cases and 11 cases,respectively. Pathological results also showed that most patients with significantly increased EOS number in the food allergy group were not accompanied by increased MCs number,and most patients with significantly increased MCs number were not accompanied by increased eosinophilic granulocytes.2.The EOS count of gastric mucosa in the food allergy group,food intolerance group and the control group was statistically significant(P<0.05).Two comparison,food intolerance group of gastric mucosa EOS count than the control group with statistical significance(P<0.05).3.MCs count of gastric mucosa in food allergy group,food intolerance group and control group was not statistically significant(P>0.05).4.The EOS count of gastric mucosa in the combination of food intolerance and Hp infection was statistically significant compared with that in the control group(P<0.05).The EOS count of gastric mucosa in the combination of food intolerance and Hp infection was also statistically significant compared with that in the group without Hp infection(P<0.05).There was no statistical significance in the EOS count of gastric mucosa after Hp infection in the combination of food allergy and Hp infection in the control group(P>0.05),and there was no statistical significance in the EOS count of gastric mucosa after Hp infection in the combination of food allergy and Hp infection in the group of food allergy and Hp infection(P>0.05).5.The MCs count of gastric mucosa after Hp infection in the food allergy group and the food intolerance group was statistically significant compared with that in the control group(P<0.05).Compared with the food allergy group without Hp infection,the MCs number of gastric mucosa was statistically significant(P<0.05).The number of MCs in gastric mucosa after Hp infection in combination with food intolerance was statistically significant compared with that without Hp infection in combination with food intolerance(P<0.05).Conclusion:1.The number of EOS and MCs in gastric mucosa increased significantly in the food allergy group and the food intolerance group compared with the control group.2.The number of EOS in gastric mucosa increased in food-intoleration-related gastric diseases.3.The number of MCs in the gastric mucosa of gastric diseases related to food allergies and the number of EOS and MCs in the gastric mucosa of gastric diseases related to food intolerance may increase after Hp infection.4.Among the gastric diseases related to food allergy and food intolerance,there were 14 cases that were consistent with the diagnosis of eosinophilic gastroenteritis,that is,food allergy and food intolerance may be related to the incidence of eosinophilic gastroenteritis.