| Objective:To investigate the risk factors of gastroesophageal reflux disease(GERD)in elderly population.Methods:Choose a number of 300 patients with gastroesophageal reflux disease diagnosed in the Department of Gastroenterology in our hospital,who were enrolled in the hospital from January 2018 to June 2018.The criteria were: 1 Due to gastrointestinal symptoms such as acid reflux and heartburn,the score of GERDQ scale were equal or great than 7,and suspected GERD,the patients were diagnosed by endoscopic gastrointestinal bleeding,digestive tract ulcers,tumors,esophageal stricture,esophageal varices and other serious organic diseases;2 The age of the patients is over 60 years old or not less than 60 years old,including male or female;3The patients did not take any acid-suppressing drugs or gastric motility drugs 4 weeks before the visit;4 The patients were informed and agreed.Exclusion criteria: 1 the patients who have been diagnosed with GERD and are in treatment with proton pump inhibitors;2 the patients who have upper gastrointestinal bleeding or surgical history,esophageal stricture,esophageal or gastric varices,peptic ulcer,esophageal and gastric tumors within 1 year before treatment;3 the patients who have other serious systemic diseases(hypertension,diabetes,coronary heart disease,etc.);4 the patients who have a history of drug abuse.300 patients with gastroesophageal reflux disease were screened and recorded as an experimental group in total,the number of reflux esophagitis were 110,non-reosive reflux disease were 183 and Barrett esophagus were 7.At the same time,300 patients with non-gastroesophageal reflux disease who were admitted to our hospital for the same period of time were selected as the control group.The Gerd Q scale and questionnaire(see Appendix 1)were used to investigate the score of GERDQ scale,gender,age,height,weight,abdominal circumference,and living habits of the two groups(drinking strong tea,eating too much,high-salt diet,spicy food,greasy food,high-sweet food,work conditions,etc.),esophageal hiatal hernia,Helicobacter pylori infection,non-steroidal anti-inflammatory drugs and other factors,the composition ratio of age,sex,weight in the two groups,other diseases which have no statistical significance except GERD(P>0.05).The data were collected and analyzed by SPASS 19.0.First,the single factor component comparison analysis was performed to obtain a statistically significant single factor with gastroesophageal reflux disease.Then,a regression analysis model was established based on this,and multivariate conditional regression analysis was performed to identify risk factors.Results:The gastroesophageal reflux disease questionnaire had a positive effect on the diagnosis of gastroesophageal reflux disease.The scores of the experimental group and the control group were significantly different,and the difference was statistically significant(P<0.05).Univariate analysis showed that nine factors including age,BMI,strong tea drinking,high-salt diet,spicy diet,eating too much,esophageal hiatal hernia,non-steroidal anti-inflammatory drugs and Helicobacter pylori infection,which correlated with gastroesophageal reflux disease,were statistically significant,P< 0.05.Multivariate conditional logistic regression analysis showed that the values of Wald?2 in BMI,esophageal hiatus and Helicobacter pylori infection were relatively large,and the Wald?2 value of BMI was 17.129,indicating that BMI is the most important risk factor for GERD in 9 factors.It is more meaningful than other risk factors.Conclusion: Healthy living habits and normal body shape can prevent the incidence of gastroesophageal reflux disease among the elderly.At the same time,eradication of Helicobacter pylori and early intervention of esophageal hiatal hernia can also help prevent the pathogenesis of gastroesophageal reflux disease. |
PDF Full Text Request