Clinical Study Of 24-hour Esophageal PH Monitoring In Prevention And Treatment Of Neonatal Aspiration Pneumonia

OBJECTIVE: Through the 24-hour gastroesophageal pH monitoring of neonates with aspiration pneumonia,the clinical significance of the prevention and treatment of neonatal aspiration pneumonia was discussed.METHODS: Among the children who were admitted to our hospital from August 2017 to October 2018 and diagnosed with neonatal pneumonia,80 patients were randomly selected as the study subjects and relevant clinical data were analyzed.The selected cases were newborns within 28 days after birth.Among them,children with infectious pneumonia were included in the control group(34 cases),and children with aspiration pneumonia were included in the study group(46 cases).The pH value of each group was dynamically and continuously monitored by a portable 24-hour pH recorder.The monitoring contents included: the number of acid reflux cycles,the longest reflux time,the percentage of pH < 4 time,the number of reflux durations > 5 min,and MinBiox-Ochoa score,statistical analysis of the two groups of sample data,and the study group after the anti-reflux treatment improved,PH value monitoring again,and statistical analysis before the treatment data,the collected data is non-normal distribution and can not be converted into Normal distribution,so the median and full distance were used.The data between groups were compared by rank sum test.The data before and after treatment were compared by paired rank sum test.The difference was statistically significant at P<0.05.Result: 1.The gender and age of the two groups were non-normal distribution data,and were described as median.The non-parametric rank sum test was used to compare the gender and age of the two groups,which was not statistically significant.,that is,age and gender are not comparable in the two sets of data,and do not affect the results of the two groups of experiments;2.In the study group(children with aspiration pneumonia)and the control group(children with infectious pneumonia),all data were non-normally distributed,described in full and median,and nonparametric rank sum test was used for both groups.The comparison between.Data comparison results showed: number of reflux cycles,longest reflux duration,pH <4 time percentage,reflux duration >5 minutes,and MinBiox-Ochoa composite score,median and full distance in the study group,respectively Significantly greater than the control group,suggesting that the number of acid reflux cycles in children with aspiration pneumonia is significantly higher than that in children with infectious pneumonia.The longest reflux time in children with aspiration pneumonia is significantly higher than that in children with infective pneumonia.The acid reflux time in the lower esophagus was significantly longer than that in children with infectious pneumonia.The children with aspiration pneumonia had a longer reflux time than the children with infectious pneumonia.Finally,combined with the comprehensive score,the pathological reflux of the lower esophagus was found in children with aspiration pneumonia.There was no obvious reflux in the lower esophagus of children with infectious pneumonia.P was 0.000<0.05,the difference was statistically significant.3.The children in the study group(abdominal pneumonia)were given postural changes,diet adjustment and drug treatment.The clinical symptoms of the children were significantly relieved.After the improvement,the children were again monitored for 24-hour esophageal pH.The test results were also used.The number of digits and the full range showed parallel non-parametric rank sum test.The statistical results indicated that the reflux index was lower than that before treatment,indicating that the reflux of children with aspiration pneumonia was significantly improved,and the difference was statistically significant(P<0.05).In Conclusion: The results of this study show that: 1.Gastroesophageal reflux is an important cause of neonatal aspiration pneumonia;2,24-hour esophageal pH monitoring is an important means to help identify the cause of neonatal aspiration pneumonia;3.According to the 24-hour esophageal pH monitoring results,the assessment of reflux and the severity of the disease has an important guiding role for early intervention measures to improve the cure rate of children.