Preparation And Antibacterial Application Of Two Functionalized Carbon Slag Composites

Bacterial adsorption on the surface of biomedical materials such as catheter or body mucosa,artificial joints secrete RNA,DNA,fibrin,polysaccharide matrix,lipopolysaccharide and other polysaccharide complexes,adhere to each other and clone to form biofilm.The biofilm forms an extracellular polymer?EPS?which is a self-protection of the microorganism during its growth.It allows bacteria to not only survive in harsh environments but also spread them into new environments.Biofilms formed by microbial bacteria in the natural environment are widely present.The surface plaque of various biological materials and the mucosal surface of the body can form a bacterial biofilm in the clinic,which has strong immune escape and drug resistance,and is one of the main causes of clinical chronic infection.Because it is resistant to antibiotics,it can only control the infection by removing the implant,which greatly increases the patient's pain and treatment costs.This requires the construction of an antibacterial film/coating/surface on the surface.The water-soluble antibacterial agent and the hydrophobic polymer may be incompatible and unevenly distributed.How to use a simple method to uniformly fuse the antibacterial water-soluble functional molecules with the hydrophobic polymer matrix to construct an antibacterial functional film/coating/surface is a technical problem to be solved.In the prior art,functional molecules are immobilized on the surface of a hydrophobic polymer matrix by means of physical adsorption or covalent grafting,and there are defects in a short functional period and a complicated process.The inorganic carrier such as zirconium phosphate silica,carbon nanotubes and graphene can be used to achieve uniform fusion of the functional molecule and the hydrophobic polymer matrix,but the carrier itself needs to be modified in advance,and the preparation process is complicated.Therefore,the research content of this paper will be explained from the following two aspects.In the one part:in This experiment uses amphiphilic carbon residue particles as carrier to graft chitosan by covalent bonding method,using vanillin and glycidyl trimethylammonium chloride?GTMAC?as modifying reagents,using chemical methods.The chitosan carbon residue particles were structurally modified.The chemical coloration qualitative test,zeta potential measurement,thermogravimetric?TG?analysis,ultraviolet spectrophotometry,Fourier transform infrared spectroscopy,dispersibility investigation and antibacterial performance test were characterized.A series of characterization methods were used to verify the successful grafting of vanillin and GTMAC.The ACPs derivatives were doped in a hydrophobic polymer thermoplastic polyurethane elastomer?TPU?matrix by solvent blending method to construct a membrane composite.Studies have found that ACPs derivatives can be consistently blended with hydrophobic polymers.The doping of ACPs derivatives not only contributes to the improvement of the polar and mechanical properties of the hydrophobic polymer matrix,but also imparts an antibacterial function.It is also proved that the functionalized carbon residue particles and film have good antibacterial properties.In this experiment,O-quaternized vanillyl chitosan carbon slag particles were successfully prepared.The particles have good amphiphilic and broad-spectrum antibacterial properties,and have very broad development prospects in the fields of cosmetic medical dressings and textiles.The second part:structural modification of chitosan,design and synthesis of a degradable material with good dispersibility,chemical stability,low toxicity and broad antibacterial spectrum.Chitosan,Ethylenediaminetetraacetic acid?EDTA?modified chitosan and chelated Ce⁴⁺were analyzed by thermophilic binding method and thermogravimetry?TG?by using amphiphilic carbon residue particles as carrier.)and so on.In this experiment,ethylenediaminetetraacetic acid chitosan carbon residue particles with chelated cerium ions were successfully prepared,which can destroy the biofilm produced by bacteria.