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The Preparation And Function Application Of The Quaternized Biological Carbonaceous Particles

Posted on:2017-12-12Degree:MasterType:Thesis
Country:ChinaCandidate:X P LiFull Text:PDF
GTID:2334330488452751Subject:Master of Chinese Pharmacy
Abstract/Summary:PDF Full Text Request
Microbial contamination presenting on the surface of the object material inevitably lead to biofilm and multi-drug resistant strains of bacteria, pathogenic infections and elasticity, and even the formation of material damage. The threat of harm to human health and cause function ineffective of medical implants and equipment, food storage and food packaging applications, biosensors and water purification systems.By using yeast cell wall prepared amphiphilic biological carbonaceous particles(ACPs) a multi-functional group of the legal system by hydrothermal synthesis, and biological carbon residue particulate graft quaternized polyethyleneimine(QPEI), thereby preparing a both anti-gram-positive bacteria such as Staphylococcus aureus(S. aureus) and Gram-negative bacteria such as Escherichia coli(E. coli) novel amphiphilic quaternary ammonium having a broad-spectrum antimicrobial properties quaternized polyethyleneimine biological carbonaceous particles(ACPs-QPEI); its particles with a hydrophobic matrix such as silicone rubber(SR) and a hydrophilic matrix such as cellulose acetate(CA) was prepared by mixing the antibacterial and antimicrobial catheters food packaging composite materials, and studied the antibacterial properties and mechanical properties of the composite material.First, by hydrothermal carbonization prepared biological carbonaceous particles, and as a drug carrier, polyethyleneimine(PEI) on through chemical covalent modification, and the method of combining successive successively adding an organic solvent such as 1-bromo hexane and methyl iodide fine particles of the tertiary and quaternary ammonium modification of the surface modification, and then through a scanning electron microscope(SEM), laser particle size and Zeta potential analyzer, Fourier transform infrared spectroscopy(FT-IR), thermal gravimetric analysis(TG) were characterized by means of quaternized polyethyleneimine biological carbonaceous particles were characterized by antibacterial final experimental tests particulate antimicrobial performance tests; by mechanical blending prepared quaternized polyethyleneimine biological carbonaceous particles / silicone rubber catheter composite membrane and quaternized polyethyleneimine biological carbonaceous particles / cellulose acetate composite membrane material, using a contact angle measuring instrument, electronic universal testing machine composite film contact angle, tensile strength, tear strength, tensile elongation at break and Shore a hardness was measured; final composite membrane was measured by its antibacterial effect in a simulated artificial fluid. Reuse experiments showed that composite films at 37 ?reused 40 times still has relatively good activity against microorganisms.Therefore, this work provides a new method for the preparation of a new broad-spectrum antibacterial composite film, quaternized polyethyleneimine biological carbonaceous particles produced have broad spectrum antibacterial activity, low volatility, low toxicity, chemically stable, it is difficult through the skin penetration and in some polar and non-polar solvents better dispersion, likely future role in some cultures in applied medical interventional catheters such as urinary catheters, endotracheal intubation or used in daily life we have contacted the antibacterial door handles, food packaging film, insoles, stair railings, elevator buttons, tap water pipe, reduce the number of bacteria and viruses and other microbes spread diseases caused by infection; or may be applied as a coating in various fields to prevent microbial Pollution.
Keywords/Search Tags:microbiological contamination, quaternized polyethyleneimine biological carbonaceous particles, antibacterial composite film, reusability
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