Effects Of Helicobacter Pylori On Biological Characteristics Of Tumor Cells In Early Gastric Cancer

Objective To elucidate the differences between the biological characteristics of tumor cells in early gastric cancer and Helicobacter pylori(HP).Methods Of the 111 patients with early gastric cancer were enrolled in this study,of whom were divided into 4 groups: 23 HP-GC patients,47 HP+ GC patients without a history of HP eradication(U-HP+ group),12 HP+ GC patients with a history of HP eradication(E-HP+ group),36 HP-GC patients without a history of HP infection(U-HP-group)and 28 HP-GC patients with a history of HP infection(I-HP-group)were enrolled in this study.We compared biological characteristics of tumor between the four group.Results Compare with the U-HP-group,the I-HP-group was more frequently in upper one third of stomach(P = 0.01).There were significantly more differentiated cancers in the HP negative group than in the positive group and mixed tumors accounted for a higher proportion in the positive group(P=0.01).Inflammatory cells infiltrated the gastric mucosa was more severe in the HP positive group than in the negative group(P=0.025).There was no significant difference in the expression of Ki67(P > 0.05).The expression of HER2 in U-HP+ group was higher(P = 0.049)than the E-HP+ group.In addition,there was a significant increase(P = 0.002)in the expression of HER2 of the HP+ group than that of the HP-group.In the HP+ group,there was a positively correlation in HP and the expression of HER2(P=0.014).Different history of helicobacter pylori infection and eradication had significant influence on TCM syndromes(P<0.01).Conclusion HP-EGC patients without a history of HP infection more frequently occurred in the upper part of the stomach.The proliferative capacity of the cancer in different HP eradication and eradication were similar,while the neoplasm invasion in HP+ EGC were increase,especially in HP+ GC with a history of HP eradication.Different history of helicobacter pylori infection and eradication had significant influence on TCM syndromes.