Study On The Changes Of Vitamin A And E Levels In Children With Repeated Respiratory Infections

Objective:Prospective study of the relationship between repeated respiratory infections and changes in serum vitamin A and E levels.Methods:Children aged 0-14 years from August 2016 to July 2018 in Children’s Hospital of Chenzhou Hospital affiliated to Nanhua University were selected and divided into children with respiratory infections and healthy children,and respiratory infections including recurrent respiratory infections and non-recurrent respiratory infections,all children or The family agreed to detect children with vitamin A and E levels in the study.According to the child’s medical history,physical examination and related auxiliary examination,the subjects were divided into three groups,including recurrent respiratory infection group,non-recurrent respiratory infection group and healthy physical examination group.The subjects included in the study were tested for serum vitamin A and E levels in children by high performance liquid chromatography-tandem mass spectrometry.The three groups were compared in pairs,and serum vitamin A and E levels were compared between the groups,and correlation data were analyzed.Results:1.Of the 1227 children enrolled in the study,366 were in the recurrent respiratory infection group(240 males and 126 females),with an average age of(5.7±3.8)years;444 children with non-recurrent respiratory infections(285 males and 159 females),the average age was(6.1±3.7)years old;417children in healthy physical examination group(254 males and 163 females),the average age was(6.1±3.8)years old.There was no significant difference in gender composition and age(P>0.05).2.(1)The levels of vitamin A and E in the recurrent respiratory infection group and the healthy physical examination group were lower than those in the healthy physical examination group(P<0.05);the vitamins in the recurrent respiratory infection group were lower than those in the healthy respiratory examination group(P<0.05).The E level was lower than that of the healthy physical examination group,and the difference was statistically significant(P<0.05).(2)The levels of vitamin A and E in children with non-recurrent respiratory infection and those in healthy physical examination group were lower than those in healthy group(P<0.05).Non-recurrent respiratory tract The level of vitamin E in the infected group was lower than that in the healthy group,and the difference was statistically significant(P<0.05).(3)Compared with the levels of vitamin A and E in the children with recurrent respiratory infection and non-recurrent respiratory infection,the level of vitamin A in the recurrent respiratory infection group was lower than that in the non-recurrent respiratory infection group(P<0.05),repeated respiratory tract.There was no significant difference in vitamin E levels between the infected group and the vitamin E level in the non-recurrent respiratory infection group(P>0.05).3.The levels of vitamin A and E in the recurrent respiratory infection group and the healthy physical examination group were lower than those in the healthy physical examination group(P<0.05);the vitamin E in the recurrent respiratory infection group The level was lower than that of the healthy physical examination group,and the difference was statistically significant(P<0.05).3.The deficiency rate of vitamin A is about 43%,the deficiency rate of vitamin E is about 2%,and the deficiency rate of vitamin A is much higher than the deficiency rate of vitamin E.4.The serum vitamin A deficiency rate was higher in the recurrent respiratory infection group than in the healthy physical examination group(χ~2=349.245,P<0.05).The non-recurrent respiratory infection group had higher serum vitamin A deficiency rate than the healthy physical examination group.The difference was statistically significant(χ~2=122.612,P<0.05).The serum vitamin A deficiency rate was higher in the recurrent respiratory infection group than in the non-recurrent respiratory infection group(χ~2=84.860,P<0.05).Conclusions:1.Serum vitamin A and E levels are reduced in children with respiratory infections.2.Children with repeated respiratory infections had lower levels of serum vitamin A than children with respiratory infections,and there was no significant change in serum vitamin E levels between the two.3.The lack of serum vitamin A increases the recurrent episodes of respiratory infections,which may be one of the important factors that cause repeated respiratory infections in children.