| Objective:1.By comparing the levels of serum RBP,folic acid,VB12 in patients with TD before and after treatment,the differences in gender and age groups with non-TD groups,and the differences in severity,clinical classification,etc.Multi-level analysis of the relationship between the disease and three observations to explore the correlation between TD and RBP,folic acid,VB12.2.Observe and compare the difference of the efficacy between Jinxinzhidong decoction combined with vitamin AD drops and Jinxinzhidong decoction lonely in the treatment of TD.Method:This study is divided into two parts.The first part is the first study,which mainly analyzes the correlation between TD and serum RBP,folic acid and VB12.The second part is the second study.The main observation is the difference of the efficacy between Jinxinzhidong decoction combined with vitamin AD drops and Jinxinzhidong decoction lonely in the treatment of TD.The subjects were all children attending the outpatient clinic of professor Han Fei.The enrolled samples were selected according to the inclusion and exclusion criteria,and all treatments strictly followed the requirements of the treatment test.Study 1 detected serum RBP,folic acid,and VB12 in the enrolled children.The TD group was treated with Jinxinzhidong decoction for 12 weeks,and the above three test indicators were reviewed.The difference between pre-treatment and non-TD was analyzed to estimate whether there was a correlation between RBP,folic acid,VB12 and TD.At the same time,gender,age stratification,analysis of RBP,folic acid,VB12,differences in the TD group before and after treatment and differences between the two groups,and TD group with different severity,clinical classification stratification,observed before and after treatment Indicator difference.Severity assessment was performed using the Yale Comprehensive Tic Severity Scale(YGTSS)score and the modified TCM syndrome symptom and grade grading scale score,and the efficacy was evaluated by the scale reduction score before and after treatment.The whole course of treatment focuses on the liver and kidney function and urine routine of the child to ensure safety.All laboratory tests were completed in the Inspection Department of Guang'anmen Hospital,and all testing procedures were carried out with strict standard curve and quality control.Study 2 used a simple randomized controlled approach to divide TD children into two groups.The experimental group was given a Jinxinzhidong decoction combined with VAD drops(capsule type),(production batch number:specifications:Va2000U.Vd700U).the control group was treated with Jinxinzhidong decoction only for 12 weeks.Severity and efficacy evaluation were the same as study 1.Emphasis was placed on the analysis of the differences in efficacy between the two groups at different ages and severity.The treatment process focuses on the liver and kidney function and urine routine of the child to ensure safety.The data analysis was performed using the statistical software SPSS24.0 system.The results obtained were significantly different at P<0.05.which was statistically significant.Otherwise,there was no statistical difference between the two groups.The measurement data are expressed as mean ± standard deviation(X±s),which conforms to normal distribution and homogeneity of variance,and uses two independent sample t test.Non-conformity adopts non-parametric Mann-Whitney U in two independent sample rank sum test.The test;the count data were compared using the composition ratio,and the chi-square test(x2 test)was used for the statistics.The rank data between the two groups was statistically analyzed by rank sum test.Paired t-test was used to compare before and after the group.One-way analysis of variance was used for comparison between groups.Strictly follow the inclusion criteria to include the sample,the professional physicians to assess the YGTSS scale and the TCM syndrome symptoms and signs grading matrix,return visits on time,emphasize the doctor's advice,timely understand and record the changes in the children's condition,select a reasonable statistical method to analyze the income data.Results:1.Study 1:Correlation analysis between tic disorder and folic acid,VB12 and RBP1.1 The final subjects included in the study 1 were 67 patients in the TD group and 50 patients in the non-TD group.The TD group was treated with Jinxinzhidong decoction for 12 weeks.The curative effect was evaluated according to the YGTSS scale and the rate of reduction:55 patients(82.09%)were effective,and 12(17.91%)were ineffective;The efficacy was evaluated according to the improvement of TCM syndromes:59 cases(88.06%)were effective and 8 cases(11.9%)were ineffective;1.2 Serum RBP levels in the TD group were lower than the normal reference range and lower than the non-TD group,the difference was significant(P<0.05).After 12 weeks of treatment with Jinxinzhidong decoction,serum RBP was significantly higher than before treatment and reached normal level.The difference was statistically significant before and after treatment.There was no significant difference between the folic acid and VB12TD groups before and after treatment(P>0.05)1.3 The effect of gender on the three test indicators:the RBP of the children in the TD group was lower than that of the non-TD group,and the male children were lower than the female children.There was no difference in RBP between different genders in the same group.The RBP of the boys in the TD group was lower than the normal range and lower than that in the non-TD group(P<0.05).The RBP of the female children in the TD group was at a normal low level before treatment,which was lower than that of the non-TD group.There was no significant change in RBP after treatment.The difference between the two groups was not statistically significant.There was no statistically significant difference in folic acid and VB12 between the two groups.1.4 There were differences in RBP between different age groups in the TD group and in the non-TD group.There were significant differences in folic acid between the two groups at different ages,but there was no difference in VB12.The RBP of children in all age groups before treatment in the TD group was lower than that in the non-TD group.The difference between the ages of 7 and 7 was statistically significant.There was no statistical significance at the age of 8 years.After treatment,the RBP of children under 7 years old was significantly increased(P<0.05).reaching the normal range,but still lower than the non-TD group;the RBP of the TD group above 8 years old was higher than that of the non-TD group,but the difference was not statistically significant.Folic acid levels showed a decreasing trend with age,and the difference between the two groups was not statistically significant.Before treatment,VB12 in TD group was higher than that in non-TD group(P<0.05),and decreased after treatment,which was equivalent to non-TD group.1.5 There was no significant correlation between severity and clinical classification and RBP.folic acid and VB12.2.Study 2:Therapeutic effect of Jinxinzhidong decoction combined with VAD drops on tic disorder2.1 Study 2 finally included 84 children with TD,including 41 in the experimental group and 43 in the control group.The curative effect was evaluated by YGTSS score.The experimental group was effective in 34 cases,ineffective in 7 cases,and the total effective rate was 82.93%.In the control group,34 cases were effective,and 9 cases were ineffective.The total effective rate was 79.07%.The difference in total effective rate between the two groups was not statistically significant.There was no statistically significant difference in the reduction scores between the two groups of YGTSS total scores,exercise tics scores,and vocal twitch scores.The YGTSS scores were compared between the two groups before and after treatment,and the differences were statistically significant.2.2 The TCM syndrome scores were used to evaluate the efficacy of the two groups.The experimental group was effective in 37 cases,ineffective in 4 cases,and the total effective rate was 90.27%.In the control group,37 cases were effective,and 6 cases were ineffective.The total effective rate was 86.45%.The total effective rate of the test group was higher than that of the control group,but the difference was not statistically significant.There was no statistically significant difference in the scores of TCM syndrome total score,heart-hepatic system score,spleen-kidney score and yin deficiency syndrome score between the two groups.The scores of TCM syndromes before and after treatment in the two groups were self-controlled,and the differences were statistically significant.2.3 For children under 7 years old,19 were effective in the control group,2 were invalid,and the effective rate was 90.18%;15 were effective in the control group,3 were invalid,and the effective rate was 75%.Children aged 8 to 12 years old,14 were effective in the control group,4 were invalid,and the effective rate was 77.78%;18 were effective in the control group,6 were invalid,and the effective rate was 75%.For children over 13 years old,1 were effective in the control group,1 were invalid,and the effective rate was 50%;1 were effective in the control group,0 were invalid,and the effective rate was 100%.There was no statistically significant difference in the effectiveness of the two groups between different age groups(P>0.05).2.4 Mild children,1 were effective in the control group,1 were invalid,and the effective rate was 50%;3 were effective in the control group,1 were invalid,and the effective rate was 75%.For moderately ill children,28 were effective in the control group,6 were invalid,and the effective rate was 82.35%;24 were effective in the control group,8 were invalid,and the effective rate was 75%.Severe children,5 were effective in the control group,0 were invalid,and the effective rate was 100%;7 were effective in the control group,0 were invalid,and the effective rate was 100%.The difference in the effectiveness of the two groups at different severity levels was not statistically significant(P>0.05).Conclusion:1.The efficacy of the Jinxinzhidong decoction stop was evaluated by the YGTSS score reduction rate and the TCM syndrome improvement rate.The effective rate was over 78%,and the TCM syndrome improvement rate was higher than the YGTSS reduction rate.The TCM syndrome was especially in the heart and liver syndrome.Seriously,it shows that the instructor's "consideration from the heart" has a precise thinking and has obvious advantages in improving the overall situation of the child.2.Serum RBP in children with TD is lower than normal,and male children ar e lower than female children.Children under 7 years old are younger than chil dren over 8 years old.RBP is significantly elevated after treatment,indicating that Jinxinzhidong decoction improves RBP levels in children with TD.The e ffect is good,and it is also suggested from the side that there is a certain cor relation between RBP and the pathogenesis of this disease.3.There was no significant relationship between the TD's severity,clinical classification and RBP,folic acid,VB12.4.The combination of VAD and Jinxinzhidong decoction alone was effective.The difference was not statistically significant,suggesting that Jinxinzhidong decoction can effectively improve RBP levels in vivo,but the mechanism still needs further study.5.All children enrolled in the group did not have liver and kidney function damage.indicating that the Jinxinzhidong decoction is safe and effective,suitable for children's physique,and is not harmful to children who need long-term medication. |
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