Correlation Between DCE-MRI Quantitative Perfusion Histogram Parameters,apparent Diffusion Coefficient And Ki-67 In Different Pathological Types Of Lung Cancer

Objective:To explore the efficacy of dynamic contrast enhanced magnetic resonance imaging(DCE-MRI)histogram molecular imaging index,apparent diffusion coefficient(ADC)in different types of lung cancer and explore their correlation with Ki-67.Methods and Materials:33 cases of lung cancer patients confirmed by pathology in our hospital from March 2017 to March 2018 were collected,including 15 cases of squamous cell carcinoma,12 cases of adenocarcinoma,and 6 cases of neuroendocrine carcinoma.All patients performed DCE-MRI and DWI imaging within one week before surgery or puncture.ADC values,DCE-MRI quantitative perfusion parameters by histogram metrics analysis(mean value,skewness,kurtosis,uniformity,entropy,energy,quantile)of Ktrans,Kep,Ve,and Vp were then collected.Determination of Ki-67 expression in lung cancer tissue by immunohistochemical method.To comparison and analysis parameters of the three groups,One-way analysis of variance and Least significant difference were used to compare the differences among the parameters of the three groups which were normal distribution and equal variances,while Kruskal-Walls test and Mann-Whitney U test were used to compare the parameters that did not conform to normal distribution or variance.Pearson correlation analysis were used to compare the correlations between quantitative perfusion histogram parameters,ADC values and immunohistochemical scores of Ki-67.Results:The Ki-67 count in neuroendocrine carcinoma and squamous cell carcinoma group was significantly higher than that in adenocarcinoma group.The correlation analysis showed that there was a significant negative correlation between ADC values and Ki-67(p=0.018,r=-0.416).And Ve(Q5,Q10)is negatively related to Ki-67(p=0.017,r=-0.420;p=0.040,r=-0.366).In squamous cell carcinoma patients,Ve(homogeneity)was significantly negatively correlated with the expression of Ki-67(p=0.033,r=-0.570).Ktrans(homogeneity)and Ve(homogeneity,Q5,Q10,Q25)were significantly positively correlated with ADC values(p value from 0.001 to 0.035;r value from 0.545 to 0.765).Conclusion:DCE-MRI quantitative perfusion histogram parameters,ADC value can evaluate the lung cancer cell proliferation activity in different pathological types.