Diagnostic Value Of Thromboelastography In Hypercoagulable State Of Membranous Nephropathy

Objective: Thrombus elasto graph(TEG)was used to investigate the related factors of hypercoagulability in patients with membranous nephropathy(MN).Methods: From SePTember 2017 to July 2018,61 patients with MN and 36 patients with miniMAl change(MCD)diagnosed by renal biopsy in the First Affiliated Hospital of Bengbu Medical College were selected as the study subjects,and 20 healthy subjects as the control group.MN and MCD patients were divided into two layers according to serum Albumin level(<20g/L or 20~30 g/L).MAin outcome measures included respoNSe time(R),angle alpha,MAximum amplitude(MA)and coagulation index(CI).TEG parameters were designed for four patients subgroups,and variance analysis was performed with the MAin effects of disease and serum Albumin respectively.Results: Linear regression analysis showed that TEG parameters of MN patients were correlated with serum Albumin(P< 0.01),and variance analysis of factor design data confirmed that serum Albumin and the MAin influence of disease were statistically significant.The R value of norMAl control group was significantly higher than that of MN subgroup,but there was no significant difference compared with MCD subgroup.The values of alpha,MA and CI in NS patients(MCD,MN)were significantly higher than those in healthy controls(P<0.05).Conclusion: In clinical thrombosis prevention,patients with MCD need to strengthen antiplatelet therapy,while patients with MN need to take anticoagulant therapy into account.TEG can evaluate the coagulation state of patients compreheNSively and accurately,which is more seNSitive than routine coagulationtest,and has a certain value for the diagnosis of hypercoagulability in MN patients.