| ObjectiveBased on conventional troatment in patients wi th colorectal cancer after operation,We take external treatment with Chinese medicine moxibustion intervention,through the evaluation of preoperative and Posstoporaitive gastrointestinal function and mood change,observe the clinical effects of moxibustion treatment of colorectal cancer surgery POFS,attempts to reveal the mechanism of moxibustion treatment of coloreetal cancer surgery POFS,so as to provide reference for research of traditional Chinese medicine in the treatment of POFS,provide scientific basis for rieh ERAS of Chinese medicine treatment.MethodsFor prospective randomized controlled clinical trials,this study collected during.June 2017 to January 2019,undergoing laparoscopic surgery in General Surgery in Guangzhou Hospital of TCM,and biopsy pathology diagnosed with coloreetal cancer(coloreetal cancer),and ctective laparoscopie colorectal cancer surgery,postoperative fatigue syndrome patients,included in the standard of 70 cases,according to the randomized,double-blind method was divided into the experimental group of 37 cases,control group 33 cases.In the control group,only conventional supportive treatment and symptomatic treatment were given after surgery,and no other intervention measures were involved.The experimental group was treated with moxibust ion on the basis of conventional treatment in the control group.Usage and treatment course:starting from the first day after the operation,moxibustion treatment should be performed at 9am and 3pm eery day for 20min,and the moxibustion treatment should be stopped until the 14th day after the operation,with the longest course of treatment not exceeding 14 days.Acupoints:double Zusanli point,Guanyuan point and Qihai point.The patients' first anal exhaust time,first defecation time ind first feeding time were observed,and their VAS,BPOMS and ICFS scale scores were evaluated ld before surgery and 3d,7d,10d and 14d after surgery.Baseline analysis and safety assessment were performed for all included cases.All data were statistically analyzed using SPSS24 software.Results1.Comparison of baseline data:(1)37 cases were included in the treatment group,while 6 cases were withdrawn;33 cases were included in the control group and 3 cases were withdrawn.There was no significant difference in treatment completion between the two groups(P>0.05).(2)there was no significant difference between the treatment group and the control group in age,gender,ASA classification before anesthesia,preoperative BMI,tumor site,operation time,intraoperative blood loss and other baseline comparisons(P>0.05).2.Comparison of outcomes:(1)compared with the control group,the first postoperative exhaust time in the treatment group was shortened by 5 hours,and the difference was statistieally significant(P<0.05).The first postoperative defecation time was shortened by 3 hours,and the difference was not statistically significant(P>0.05).The time of first feeding after surgery was shortened by 7 hours in the treatment group,and the difference was statistically significant(P<0.05).(2)VAS scale score:compared with the control group,there was no significant difference in VAS scale score at 1d before surgery and 1d,10d and 14d after surgery(P>0.05),while there was significant difference in VAS scale score at 3d and 7d after surgery(P<0.01).In the treatment group,the VAS scale score decreased gradually afLer treatment,and there were significant differences in the VAS scale score at 1d,3d,7d,10d and 14d after surgery(P<0.01).In the control group,VAS scale score decreased gratdually after treatment,and there were significant differences in VAS scale scores at 1d,3d,7d,10d and 14d after surgery(P<0.01)compared with 1d before surgery.(3)BPOMS scale score:compared with the control group,there was no significant difference in BPOMS scale score between the treatment group at 1d before surgery and 7d,10d and 14d after surgery(P>0.05).The BPOMS scale score of the treatment group was lower than that of the control group 3 days after surgery(P<0.05).In the treatment group,BPOMS score decreased gradually after treatment,and there was no significant difference in BPOMS score at 7d,10d and 14d after surgery(P>0.05),while there was significant difference in BPOMS score at 3d after surgery(P<0.01).In the control group,BPOMS score decreased gradually after treatment,and there was no significant difference in BPOMS score at 7d,10d and 14d after surgery(P>0.05),while there was significant difference 3 days after surgery(P<0.01).(4)ICFS scale score:compared with the control group,there was no significant difference in ICFS scale score between the treatment group 1 day before surgery and 3,7 and 14 days after surgery(P>0.05).The ICFS scale score of the treatment group 10 days after surgery was lower than that of the control group(P<0.01).In the treatment group,ICFS score decreased gradually after treatment,and there was no significant difference in ICFS scale score between 10d and 14d after surgery(P>0.05),and significant difference between 3d and 7d after surgery(P<0.01).In the control group,ICFS score gradually decreased after treatment,and there was no significant difference in ICFS scale score at 14 days after surgery(P>0.05),and significant difference at 3,7 and 10 days after surgery(P<0.01).ConcliusioonPOFS was common in postoperative patients with colorectal cancer,lasting about 7-14 days,with a tendency of self-healing.Moxibustion on double Zusanli point,Guanyuan point and Qihai point can relieve POFS and reach the ERAS target by improving postoperative gastrointestinal function and mood changes of patients. |
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