| Objective:After long-time research and Practice,Modern Chinese Medicine agreed that the main Pathological basis of Deep Vein Thrombosis(DVT)is stagnation of Phlegm and blood,and damp invasion of lower energizer.It' s an important stage that Phlegm and blood stasis syndrome which is throughout the whole course of DVT.To observe the clinical efficacy of the method Softening hardness and dissipating mass for the treatment of DVT differentiated as Phlegm and blood stasis syndrome.In order to improve the effectiveness of treatment,increase the sensitivity of the Body to anticoagulant drugs,Promote vascular endothelial cell repair,and decrease blood viscosity.In this way,we can use less dosage to achieve better efficacy,accelerate vascular recanalization,Promote collateral vessel establishment,shorten the period of treatment,and reduce the risk of recurrence.Methods:One hundred and twenty DVT of lower limb(s)patients with Phlegm and blood stasis syndrome were randomly divided into trial group(n=60)and control group(n=60).The two groups were given conventional western medicine treatment,and additionally the trial group was given oral use of Xin Mai Kang tablets.The two groups were treated continuously for 3 months.Before enrollment,and on the 1st,2nd,4th,8th and 12th week after enrollment,the scores of traditional Chinese medicine(TCM)symptoms,limb circumference difference,international normalized ratio(INR),drug dose of Warfarin,nitric-oxidesynthase(NOS),blood liPid,blood rheology,Color Doppler Ultrasound of venous veins of lower limbs,Magnetic resonance venography(MRV)of lower limbs in the two groups were compared.After treatment,the clinical efficacy of the two groups was evaluated.The patients should quit the trial once complicated with acute complications during the trial.Using SPSS 21.0 statistical software for analysis,measurement data expressed by x ± s,paired samples T test was used before and after treatment.Two independent samples Ttest was used for comparison between groups.Chi-square test was used to test the difference of composition ratio between groups.When P<0.05,the results showed significant difference.Results:(1)There were six and fourteen withdrawals from the study in the experimental group and the control group,54 cases were included in the experimental group and 46 cases in the control group actually.(2)A total of 100 patients were included in this study,26 males and 20 females in the control group,while 31 males and 23 females in the experimental group.The average age was 58.48 in the control group and 59.87 in the experimental group.The average course of disease was 1.590 months in the control group and 1.733 in the experimental group.There were 2 cases with history of venous thrombosis,28 with hypertension,17 with diabetes,12 with coronary disease and 5 with rheumatic immune diseases in the control group,while 3 cases with history of venous thrombosis,31 with hypertension,15 with diabetes,15 with coronary disease and 3 with rheumatic immune diseases in the experimental group.There was no significant difference between the groups.(3)After three months of treatment,the efficacy rates were 88.89%vs 69.57%for the experimental group and control group respectively,which had significant difference between the groups,and the efficacy of the experimental group was better than the control group.(4)The maintenance dose of warfarin was(3.06±0.68 mg qn)in the control group and(2.78±0.50 mg qn)in the experimental group,which had significant difference between the groups,and the maintenance dose of the experimental group was lower than the control group.(5)The measurement of nitric-oxidesynthase(NOS)between the experimental group and the control grouP had significant difference after 3 months of treatment,and the measurement of NOS in the experimental group was higher than the control group.(6)The hemorheology between the experimental group and the control group had significant difference after 3 months of treatment,and the hemorheology in the experimental group was lower than the control group.(7)The the scores of traditional Chinese medicine(TCM)symptoms between the experimental group and the control group had significant difference after 3 months of treatment,and the scores in the experimental group was lower than the control group.(8)The the scores of clinical symptoms between the experimental group and the control group had significant difference after 3 months of treatment,and the scores in the experimental group was lower than the control group.(9)After three months of treatment,the vascular recanalization rate were 68.52%vs 52.17%for the experimental group and control group respectively,which had significant difference between the groups,and the vascular recanalization of the experimental group was higher than the control group.(10)After three months of treatment,the establishment rate of collateral circulation were 31.48%vs 19.57%for the experimental group and control group respectively,which had significant difference between the groups,and the establishment of collateral circulation of the experimental group was higher than the control grouP.Conclusion:Adding Xin Mai Kang tablets on the basis of standard anticoagulant therapy under the guidance of guidelines can improve the efficiency of treatment in DVT differentiated as Phlegm and blood stasis syndrome,increase the sensitivity of the Body to anticoagulant drugs,promote vascular endothelial cell repair,and decrease blood viscosity.In this way,we can use less dosage to achieve better efficacy,accelerate vascular recanalization,promote collateral vessel establishment,shorten the period of treatment,and reduce the risk of recurrence.It proves that the method Softening hardness and dissipating mass for the treatment of DVT differentiated as Phlegm and blood stasis svndrome has definite curative effect. |
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