Relationship Between Body Mass Index And NT-proBNP In Stable Coronary Heart Disease

Background:Brain natriuretic peptide is a well-characterized marker of heart failure and will be significantly elevated in cardiac dysfunction.Obesity is one of the risk factors for cardiovascular disease such as heart failure.However,many studies about cardiovascular disease have found an inverse correlation between body mass index and plasma brain natriuretic peptide concentrations.This study will aim to investigate the relationship between body mass index and the level of NT-proBNP in stable coronary heart disease patients without heart failure.Methods:Patients with stable coronary artery disease and without heart failure were selected,who were hospitalized from June 2015 to August 2018 in the cardiovascular department of Ningbo Hospital of Zhejiang University,underwent coronary angiography.Group by body mass index,all patients were divided into 4 groups:underweight group,normal weight group,overweight group and obesity group.The factors affecting the plasma NT-proBNP level were studied by statistical analysis,to determine the effect of body mass index on NT-proBNP,and the possible causes and mechanisms.Results:A total of 656 patients met the study conditions(median 74 years old,male 67.84%),the obesity group contained 81 patients(12.35%).Left atrial diameter,Left ventricular end diastolic diameter and Left ventricular mass in the obesity group were significantly higher than other groups,but there was no significant difference in left ventricular ejection fraction and left ventricular mass index between the groups.Gender,smoking,hypertension,diabetes,atrial fibrillation,blood pressure,pulse,previous history of coronary intervention,total cholesterol,triglyceride,fasting glucose level,Gensini score,triple-vessel disease proportion,coronary interventional therapy this time were all no statistic difference(P>0.05).The level of plasma NT-proBNP and its logarithmic values in the overweight or obesity group were significantly lower than those in the underweight and the normal weight group(P<0.05).Multiple linear regression analysis showed a significant inverse correlation between BMI and NT-proBNP levels in stable coronary heart disease patients without heart failure(r=-0.05,P<0.0001).Conclusions:In patients with stable coronary heart disease without heart failure,there is an inverse correlation between body mass index and plasma NT-proBNP concentrations.The level of plasma NT-proBNP in patients with coronary heart disease who are overweight or obese,is much lower than those in normal weight and underweight patients,but the specific reasons are not clear currently.