| Objective:To compare the stability of neonatal parenteral nutrition containing two different water-soluble vitamins,and to investigate the stability of parenteral nutrition at different temperature.To compare the clinical efficacy of nutritional supplements in preterm infants with different water-soluble vitamins.The difference between the two water-soluble vitamins for injection is that water-soluble vitamins for injection of manufacturer A excludes the bacteriostatic methylparaben and water-soluble vitamins for injection of manufacturer B contains the bacteriostatic methylparaben.Methods:1.The effects on the stability of neonatal parenteral nutrition containing different water-soluble vitaminsTo use 1.5 mL and 3.0 mL of the mixture of water-soluble vitamins and fat-soluble vitamin injection to prepare respectively the parenteral nutrition of the low-dose and the high-dose groups,and the manufacturer A and the manufacturer B of the water-soluble vitamins were respectively prepared the the control and the experimental group of the parenteral nutrition.Under room temperature,the effects of different water-soluble vitamins on the stability of neonatal parenteral nutrition were investigated by the appearance properties,pH value,droplet size and distribution,number of insoluble particles and bacterial growth.2.Under three storage temperature,to study the effect on neonata parenteral nutritionTo use 1.5 mL of the mixture of water-soluble vitamins and fat-soluble vitamin injection to prepare parenteral nutrition,and the manufacturer A and the manufacturer B of the water-soluble vitamins were respectively prepared the the control and the experimental group of the parenteral nutrition.Under three different temperatures(4?,25?,40?),the effect of storage temperature on parenteral nutrition were investigated by the appearance,pH value,droplet size and distribution,the number of insoluble particles,bacterial growth of parenteral nutrition.3.To compare the clinical efficacy of parenteral nutrition containing different water-soluble vitamins in nutritional support of infantsFrom December 2016 to February 2017 and from December 2017 to February 2018,retrospective analysis of data from 60 hospitalized children who were unable to fully tolerate gastrointestinal feeding.The children who used the parenteral nutrition containing the water-soluble vitamin of the manufacturer A were used as the control group,and the children who used the parenteral nutrition containing the water-soluble vitamin of the manufacturer B were used as the experimental group.The body weight,blood glucose,nutritional indicators,liver function indicators and the content of electrolyte were compared.Results:1.The effects on the stability of neonatal parenteral nutrition containing different water-soluble vitaminsThere were no significant difference in the pH value and droplet size of the parenteral nutrition between the experimental and the control group in the low-dose and the high-dose groups(P>0.05),and The difference in PDI values were statistically significant(P<0.05),and the PDI values of the parenteral nutrition in the experimental group were bigger than those in the control group.The sterilized test and the insoluble microparticle test results of the two groups were in compliance with the provisions of the Chinese Pharmacopoeia(2015 edition).In the low-dose and the high-dose groups,thecolor of the experimental group was yellower than that of the control group of the parenteral nutrition.2.Under three storage temperature,to study the effect on neonata parenteral nutritionTo compared with 4 ? and 25 ?,the difference in the size of the droplets at 40 ?of the two groups were statistically significant(P<0.05),and at 40 ?,the number of the insoluble microparticles of two parenteral nutrition does not meet the requirements of the Chinese Pharmacopoeia(2015 edition)and showed slight emulsification after 24 h.3.To compare the clinical efficacy of parenteral nutrition containing different water-soluble vitamins in nutritional support of infantsBetween the control and the experimental group,there were no significant differences in body weight,nutritional indicators,liver function indexes,blood glucose(Glu),and electrolyte(sodium,potassium,and chlorine)before and after parenteral nutrition support(P>0.05).In the same group,there were significant differences in body weight,albumin(ALB),proprotein(PA),total protein(TP),blood glucose(Glu),and unconjugated bilirubin(P< 0.05).Conclusion:1.Two kinds of neonatal parenteral nutrition formulated with water-soluble vitamins for injection have better stability which can be used as vitamin supplements.The distribution of parenteral nutrition prepared by water-soluble vitamins of manufacturer A were relatively well.2.Under 4 ?,25 ? temperature,the stability of parenteral nutrition were well within 24 h.If it cannot be used immediately,we should avoid to place it under high temperature conditions to ensure the stability of the parenteral nutrition.3.The parenteral nutrition containing two kinds of water-soluble vitamins can meet the energy and nutrient requirements of newborn growth and development.In order to ensure the safety and effectiveness of parenteral nutrition support treatment and reduce the occurrence of related complications,it is recommended that physicians will consider intravenous nutrition support treatment and other clinical treatments,and regularlymonitor and evaluate children with nutritional support treatment.4.Although this study shows that the water-soluble vitamins containing bacteriostatic methylparaben has little effect on the stability and clinical efficacy of neonatal parenteral nutrition,the safety of the antibacterial agent contained in the injection should be taken seriously. |
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