Study Of Relationship Between Helicobacter Pylori Infection And Macrovascular Complications In Type 2 Diabetes Mellitus

Objective: To study the relationship between helicobacter pylori infection and macrovascular complications in type 2 diabetes mellitus.Methods: Admitted to the endocrinology department of our hospital from February 2016 to February 2017,60 patients with type 2 diabetes mellitus were selected.Venous plasma of these type 2 diabetes mellitus patients was extracted for anti-Hp antibody test.The mouse anti-human IgG monoclonal antibody(horseradish peroxidase marker)which Huamei bioengineering company produced,was used to detect whether the Hp-IgG antibody was positive.Additionally,the Hp-IgG antibody was re-tested on the blood sample with positive Hp-IgG antibody by using the ASSURE(Hp-IgG antibody)detection kit produced by Genelabs of Singapore.Following above procedures,finally confirm the presence of helicobacter pylori infection.The patients were classified into groups as either infected(n=30)or uninfected(n=30),according to whether they were complicated with Hp infection.The blood lipid level,glycosylated hemoglobin level,peripheral blood inflammatory response marker level and macrovascular complications of type 2 diabetes mellitus were statistically analyzed.SPSS 22.0 was applied for the statistical analysis.The measurement data were expressed as mean plus or subtract standard deviation(?X±S).The comparison between the two groups was conducted by t-test.The comparison between counting data was conducted by chi-square test.The correlation between the two variables was measured by Pearson correlation coefficient.The difference was statistically significant when the P <0.05.Results: TG and LDL-C levels in the infected group were higher than those in the uninfected group,and the differences were statistically significant(P=0.002,0.000).HDL-C levels were significantly lower than those in the uninfected group,and the differences were statistically significant(P = 0.022).But the differences in TC and HbA1 C levels between the two groups were not significant(P=0.567,0.891).The levels of CRP in peripheral blood and WBC of patients in the infected group were significantly higher than those in the uninfected group,and the differences were statistically significant(P =0.001,0.007).The levels of platelets and fibrinogen in peripheral blood of patients in the infected group were lower than those in the uninfected group,but the differences between the two groups were not statistically significant(P =0.194,0.249).The incidence rates of lower limb vascular disease,coronary heart disease,and cerebrovascular disease in the two groups were 26.67% vs.6.67%,56.67% vs.26.67%,43.33% vs.16.67%,respectively.The infected group was significantly higher than the uninfected group,and the difference was statistically significant(P =0.038,0.018,0.024).Conclusions: Helicobacter pylori infection can trigger and aggravate inflammation in type 2 diabetes mellitus,also can change the balance of serum lipid metabolism,and then promote endothelial damage and atherosclerosis.Therefore,Helicobacter pylori infection is a risky factor for macrovascular complications in type 2 diabetes mellitus.