Correlation Between Metabolic Factors And Renal Cancer

Objective1.We summarized the clinical data of the patients with renal cancer and the control group,and analyzed the characteristics of the renal cancer.2.We divided into the renal cancer group and the control group,and analyzed the correlation between the factors of the metabolic syndrome and the renal cancer by using the conditional Logistic regression analysis.3.We investigated the correlation between metabolic factors of renal cancer patients and the pathological features,classification and stage.MethodsI.From December 2013 to September 2017 in Zhongda Hospital,we included 208 cases of renal cancer patients as case group,gender-and age-matched physical examination people from January 2014 to March 2017 in Zhongda Hospital without tumor as control group.1.A case-control study was carried out.we collected age,sex,smoking and alcohol use,height,body mass index,medical history,blood glucose,blood lipid.We used t test to analyze the relationship between metabolic factors and renal cancer.2.Factors with differences was performed conditional Logistic regression analysis: HDL-c,TC,LDL-c,history of hypertension,history of diabetes.3.The correlation between the various factors of metabolic syndrome and renal cancer was analyzed,including four aspects: hypertension,hyperglycemia,hyperlipidemia and obesity.II.The metabolic factors of 208 patients with renal cancer were analyzed retrospectively.According to the metabolic syndrome,it was divided into renal cancer group and renal cancer with metabolic syndrome.1.The differences in the classification of renal cancer between the two groups were analyzed.2.The correlation between the components of the metabolic syndrome and the classification of renal cancer was analyzed.Results1.General information: a total of 208 cases of renal cancer were collected,including 133 male(63.9%),75 female(36.1%),the male to female ratio was 1.8:1,the age of the patients was 32-84 years old,with an average of(57.2±12)years.151 cases of clear cell carcinoma(72.6%),19 cases of papillary carcinoma(9.1%),15 cases of chromophobe cell carcinoma(7.2%),25 cases of other special types of malignant renal tumors(12%).We took physical examination people as control group,200 male(64.1%),112 female(35.9%),age 32-84 years,average(57.3±10)years.The basic characteristics of the renal cancer group and the control group showed that there was no statistical significance and comparability between the male and female.There was no significant difference in smoking history,BMI abnormalities(including overweight and obesity)between case group and control group.The incidence of hypertension,diabetes and dyslipidemia in case group was higher than that in control group,the difference was statistically significant.2.Single factor and multiple factors analysis of metabolic factors and renal cancer: the univariate analysis showed that between the case and control group,according to the data,two groups had no statistically significant difference in BMI,serum triglyceride,had statistically significant difference in fasting blood glucose,LDL-c?HDL-c.According to the criteria of abnormal blood lipid level,we divided into two groups,there was no significant difference in the number of patients with hypertriglyceridemia.there was significant difference in the number of patients with hypercholesterolemia,low high-density lipoprotein cholesterol,low density lipoprotein cholesterol.The results of Logistic regression analysis showed that the included variables included LDL-c,HDL-c,TC,the history of hypertension,and the total history of diabetes.Results: the history of hypertension(HR=2.85,95% CI 1.803-4.517),LDL-c(HR=3.57,95% CI 2.476-5.134),TC(HR=6.9,95% CI 4.334 to 10.996),diabetes(HR=1.72,95% CI 1.070-2.760)was positively correlated with the risk of renal cancer,HDL-c(HR=0.035,95% CI 0.016-0.079)was negatively correlated with the risk of renal cancer.3.Multivariate analysis of dyslipidemia and renal cancer: according to the 2016 "China adult dyslipidemia prevention guide",we divided dyslipidemia into normal and abnormal group,Logistic regression analysis showed that including variables included high LDL-c hyperlipidemia,low HDL-c and high TC.The results showed that high LDL-c(HR=2.735,95% confidence interval was 1.597-4.686),low HDL-c(HR=3.85,95% confidence interval 2.354-6.286)and high TC(HR=2.505,95% confidence interval 1.634-3.842)increased the risk of renal cancer.4.The distribution of metabolic factors in case group and the control group: The distribution of metabolic factors in case group and the control group,according to the 4 factors of metabolic syndrome: hypertension,high blood sugar,high blood lipid and obesity.When meeting more than three,the diagnosis of metabolic syndrome could be made.Analyzing 3 or more metabolic disorder distribution in case group and control group.The results showed that more than 3 kinds of metabolic disorders in the case group were significantly higher than those in the control group,and the difference was statistically significant.5.The correlation between metabolic syndrome and renal cancer grading: according to the inclusion study,whether renal cancer patients have metabolic syndrome or not,we divided them into renal cancer combined with metabolic syndrome and renal cancer.Renal cancer combined with metabolic syndrome group contains 64 patients,the average age was(60.8±13.6)years old,42 cases of clear cell cancer,22 cases of patients with other type of renal cancer,Fuhrman classification I,II was 36 cases,Fuhrman III,IV was 28 cases;renal cancer group contains 144 patients,average age(55.6±10.5)years old,109 cases of patients with clear cell cancer,35 cases of patients with other type of renal cancer,Fuhrman classification I,II was 109 cases,Fuhrman III,IV was 35 cases.No significant difference between the two groups of patients with pathological type(P=0.133).The age and Fuhrman classification of patients with renal cancer with metabolic syndrome were higher than those of renal cancer group,and there was statistical significance(P=0.004,P=0.003).6.Correlation between metabolic syndrome components and level of renal cancer: renal cancer Fuhrman grade between the two groups: BMI anomaly(BMI > 25kg/m2),hypertension,hyperglycemia and dyslipidemia were no significant difference.(P=0.117,P=0.265,P=0.067,P=0.411).Conclusion1.The incidence of renal cancer may be associated with hypertension,hyperglycemia,dyslipidemia and other metabolic factors,high LDL-c level and low HDL-c level,high TC levels may increase the risk of renal cancer;and comparing with non-tumor,non-metabolic related diseases people,patients with renal cancer may more likely to have 3 or more metabolic disorders.2.The age and degree of malignancy of the patients with renal cancer with metabolic syndrome were significantly higher than those in the renal cancer group.