Relationship Between Serum YKL-40,GDF-15,Carotid Atherosclerosis And Severity Of Coronary Artery Disease In Patients With Acute Coronary Syndrome

Objective:This study mainly explored the relationship between serum GDF-15,YKL-40 levels,the severity of carotid atherosclerosis and severity of coronary artery disease in patients with acute coronary syndrome.Methods:From January 2018 to July 2018,62 patients who diagnosed as acute coronary syndrome in the Department of Cardiology,Second Affiliated Hospital of Chengde Medical College,were selected as the acute coronary syndrome group(ACS group,n=62).According to the coronary SYNTAXⅠscore,the ACS components were divide into low group(n=24),middle group(n=22)and high group(n=16),and 40 patients with normal coronary angiography as control group(control group,n=40),a total of 102 cases,aged between 30-80 years old.The gender,age,and body mass index of the selected subjects were measured.Record the past history of the candidate’s smoking history,hypertension,and diabetes.The biochemical parameters such as Low-density lipoprotein cholesterol(LDL-C)and creatinine(Cr)were measured.The serum levels of GDF-15 and YKL-40 in all selected patients were determined by ELISA.The carotid artery status of all enrolled patients was measured and the carotid plaque Crouse scores was calculated.Coronary angiography was performed on the subjects,and the SYNTAXⅠscore was calculated by using computer software based on the image results.Independent-samples t-test were used in the ACS group compared with the control group.One-way ANOVA was used for comparison between groups.If there was statistical difference,the SNK-q test was used to further verify.;the percentage comparison was performed byχ~2 Test;the mutivariate statistical analysis was performed by Logistic Regression Analysis;The test level was0.05.The count data was compared multiple times,and the adjusted test level was 0.008.Results:1 General data comparison1.1 There were significant differences in gender,diabetes,and smoking history between the ACS group and the control group.There showed no significant differences in age,low-density lipoprotein cholesterol,creatinine,body mass index,and hypertension.1.2 There displayed no significant difference in age,gender,low-density lipoprotein cholesterol,creatinine,body mass index,hypertension,diabetes and smoking history between the low group and the control group.1.3 It is statistically shown differences in diabetes between the group and the control group,but no significant differences shown in age,low-density lipoprotein cholesterol,creatinine,body mass index,hypertension,gender,and smoking history.1.4 There revealed significant differences in gender,diabetes,and smoking history between the high group and the control group,but no significant difference displayed in age,low-density lipoprotein cholesterol,creatinine,body mass index,and hypertension.1.5 As statistically demonstrated,no significant differences in age,gender,low-density lipoprotein cholesterol,creatinine,body mass index(BMI),hypertension,diabetes,and smoking history among the low,middle,and high groups.2 Comparison of serum GDF-15,YKL-40 levels and carotid plaque crouse scores in patients2.1 Compared with the control group,serum GDF-15,YKL-40 levels and carotid plaque crouse scores were significantly increased in the ACS group,the difference was statistically significant.2.2 High-group patients with serum GDF-15,YKL-40 levels and carotid plaque crouse scores were significantly higher than the middle group,low group and control group,the serum group GDF-15,YKL-40 level and carotid plaque crouse The scores were significantly higher than those of the low group and the control group.The serum GDF-15,YKL-40 levels and carotid plaque crouse scores in the low group were significantly higher than those in the control group.3 Ordered logistic regression analysis of risk factors for coronary SYNTAX I scoreIt is statistically presented that with the increase of serum GDF-15,YKL-40 levels and carotid plaque crouse scores,the coronary artery SYNTAX I score increased in ACS patients,and the three were risk factors for coronary artery SYNTAXⅠscore in ACS patients.The difference was statistically significant.Conclusion:The serum levels of GDF-15,YKL-40 and carotid atherosclerosis were positively correlated with the severity of coronary artery disease in patients with acute coronary syndrome.