Changes Of Serum Giα-2 And NGAL In Type 2 Diabetes And Different Classification Of Hypertension Patients And Its Clinical Value

Objective:To investigate the changes of serum Giα-2 and NGAL in type 2 diabetes and different classification of hypertension and its clinical value.Methods:A total of 237 people from September 2016 to May 2018 were selected into this study.They were divided into 40 cases of people without diabetes and hypertension(NC group),45 cases of simple diabetes(DS group),47 cases of diabetic and grade 1 hypertension patients(DH1 group),51 cases of diabetic and grade 2 hypertension patients(DH2 group)and 54 cases of diabetic and grade 3 hypertension patients(DH3 group).The serum Giα-2 and NGAL levels of subjects were detected by ELISA.Simultaneously,clinical parameters including FPG,TC,TG,ALT,Scr and HbA1 c were measured.Giα-2,NGAL and clinical indicators were compared by one-way ANOVA.The level of Giα-2,NGAL and influence factors were analyzed by multiple linear stepwise regression analysis.P<0.05 had statistical significance.Results:The level of Giα-2 in NC group was higher than that in DS group,at the same time,the levels of Giα-2 in DH1,DH2 and DH3 group were higher than DS group,the highest was DH3 group(all P<0.05).The level of NGAL in DS group was higher than NC group,when blood pressure increased,NGAL increased in DH1,DH2 and DH3 group(all P<0.05).The result of the Pearson correlation analysis showed that Giα-2 was positively correlated with SBP,DBP,duration of hypertension,duration of diabetes and NGAL(r were 0.587,0.433,0.445,0.140,0.419,respectively,P<0.05 or P<0.01),as well as NGAL was positively correlated with SBP,DBP,duration of hypertension,duration of diabetes,TC,TG,FBG,HbA1 c and Giα-2(r were 0.668,0.476,0.473,0.309,0.131,0.129,0.216,0.218,0.419,respectively,P<0.05 or P<0.01).Further multiple linear regression analysis showed that SBP was independently correlated with Giα-2 level,in the meantime,SBP and FBG were remarkablely influenced with NGAL level.Conclusion:Serum levels of Giα-2 and NGAL increased in type 2 diabetes and hypertension.The changes of levels of Giα-2 and NGAL had a certain influence on the occurrence of diabetes and hypertension.