| Objectives To observe the clinical effect of long-term decremental method for treating UlcerativeColitis large intestine and damp-heat type with Sanqi Ejiao Suppository.Methods Ninety patients who met the study criteria in the anorectal department of Tangshan Hospital of traditional Chinese medicine were divided into two groups according to the random number table method: the treatment group(Sanqi Ejiao Suppository longterm decremental administration group)and the control group(mesalaqin suppository continuous administration group),with 45 patients in each group.The gender,age,course of disease and severity of the two groups were statistically analyzed by P>0.05,which was comparable.In the treatment group,Sanqi Ejiao Suppository in our hospital was treated for3 months with the method of decreasing the length of treatment,that is,in the first month,1 suppository was given in the early and 2 suppositories in the late;in the second month,the suppository was given in the early and 1 suppository was given in the late;in the third month,the suppository was adjusted again,and only 1 suppository was given in the evening.The control group was treated with mesalaqin suppository(Falk Pharma Gmbh,imported drug registration number: H20140948,specification: 0.5g/ tablet)for 3 months in a row,that is,the subjects were treated with suppository 1 tablet earlier and 1 suppository later in 3 months,without dose addition or reduction.Primary and secondary symptom scores,microscopic mucosal scores and safety scores of the two groups were recorded and determined respectively before treatment,30 days,60 days and 90 days after medication.Patients were followed up for another 3 months after the end of the 3-month study to observe the recurrence.Results 1 Comparison of symptom scores: The main symptoms were abdominal pain,diarrhea,mucous pus and blood stool,and changes in the score of tenesmus: at 90 days after treatment,the score of mucous pus and blood stool was the main symptom of the two groups,P>0.05 was compared between the two groups,and the difference was not statistically significant.2)secondary symptoms,namely anal heat,abdominal distension and urination deficit score changes:(1)after 30 days of treatment,the scores of anal heat and urination deficit were P>0.05,with no statistically significant difference.Abdominal distension integral P<0.05,the difference was statistically significant.(2)60 days after treatment: the score of symptoms of anal burning was P>0.05,and the difference was not statistically significant.The score of abdominal distension and short urine deficit was P<0.05,and the difference was statistically significant.(3)at 90 days after treatment,the scores of anal burning and abdominal distension were P>0.05,with no statistically significant difference.The score of urine deficit symptom was P<0.05,and the difference was statistically significant.2 Clinical efficacy evaluation: 1)on the 30 th day of treatment:the sum of clinical recovery + significant efficiency in the treatment group was 33.33%,and the total effective rate was 91.11%;the sum of clinical recovery + significant efficiency in the control group was 6.67%,and the total effective rate was 86.67%,with a P value of 0.006(P<0.05),and the difference was statistically significant.2)on the 60 th day of treatment: the sum of clinical recovery + significant efficiency in the treatment group was 68.89%,and the total effective rate was 91.11%;the sum of clinical recovery +significant efficiency in the control group was 28.89%,and the total effective rate was91.11%,with P value less than 0.001(P<0.001),and the difference was statistically significant.3)90 days after treatment: the sum of clinical recovery + significant efficiencyin the treatment group was 77.78%,and the total effective rate was 91.11%;the sum of clinical recovery + significant efficiency in the control group was 60.00%,and the total effective rate was 88.89%,with a P value of 0.839(P>0.05),showing no statistical significance.3 Comparison of mucosal score under microscope: the median application of mucosal score(interquartile interval)indicated that,1)after 30 days of treatment,the score in the treatment group was 1.00(1.00-2.00),and that in the control group was 2.00(1.00-2.00),with a P value of 0.006(P<0.05),and the difference was statistically significant.2)treatment for 60 days: the treatment group had a score of 1.00(0.00-1.00),and the control group had a score of 1.00(1.00-1.00),with a P value of 0.037(P<0.05),and the difference was statistically significant.3)90 days after treatment: the score of mucosa was 0.00(0.00-0.00)in the treatment group and 1.00(0.00-1.00)in the control group,and the P value was0.15(P>0.05),with no statistical significance.4 Comparison of recurrence after 3 months of withdrawal: during the 3 months of follow-up,1 patient in the treatment group had recurrence,with a recurrence rate of 2.50%,and 7 patients in the control group had recurrence,with a recurrence rate of 17.50%.After statistical analysis by chi-square test,the 2 value was 5.160,and the P value was 0.023(P<0.05),the difference was statistically significant.5 Safety assessment: no adverse side effects were observed in patients of the two groups.Conclusions Sanqi Ejiao suppository with long course descending method for the treatment of ulcerative colitis and large intestine damp-heat type,in the first two months of the main clinical symptoms,some of the secondary symptoms in different periods,in the first two months to promote the intestinal mucosal repair and reduce the recurrence rate and other aspects,the continuous administration of meisala qin suppository has a considerable effect,which is worthy of clinical promotion and application.Figure2;Table17;Reference 132. |
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