Clinical Study On The Treatment Of Dry Eye By Music Combined With Traditional Chinese Medicine Based On Liver-Regulating Method

Objective: With the increasing of pressure from the fast-paced life in modern society,meanwhile,the popularity of cellphones,computers and other visual display terminal,the morbidity of dry eye(DE)in China has increased year by year,which affected people’s physical and mental health seriously.In this study,we treated DE by using the method of liver-regulating in traditional Chinese medicine treatments and observed the effect of music attached with Tiaoganrunmu decoction and acupuncture.Furthermore,Clinical perspectives of differentiation and treatment of DE were further discussed.Methods: In strict accordance with the diagnostic criteria,inclusion criteria and exclusion criteria of DE,60 patients from ophthalmology in Hospital of Traditional Chinese Medicine of Hebei Province were selected and randomized divided into two groups: treatment group(N=30)and control group(N=30)from Nov.2017 to Oct.2018.No significant difference was found in age and gender between the two groups after statistical process(P>0.05).The treatment group was exposed to self-made Tiaoganrunmu decoction(Including: Radix bupleuri,Scutellaria baicalensis,Rehmannia,Glossy privet fruit,Dendrobe,Rhizoma anemarrhenae,Angelica sinensis,Radix paeoniae alba,Root of common peony,Semen cassia,Rose,Poria cocos,Cicada slough,Hurricane lamp,Liquorice)plus and minus,acupuncture(acupoint: Cuanzhu,Taiyang,Chengqi,Fengchi,Yiming,Jingming,Baihui,Shenmen,Neiguan,Sanyinjiao,Taixi,Taichong),music(《hu jia shi ba pai》),artificial tears and non-steroidal anti-inflammatory eye drops;While control group was only given artificial tears and non-steroidal anti-inflammatory eye drops.15 days as one period of treatment,2 periods in total.The changes of clinical symptom integrals,tear break-up times(BUT)and the Integrals ofcorneal fluorescein stain test(FLT),schirmer I test(SIT),in both two groups were observed and recorded before and after the intervention.Then all the data was processed through the statistical methods.Results:1.Comparison between the two groups of patients before treatment: On gender,age,the clinical symptom integral,SIT,BUT and FLT integrals of the two groups were compared before treatment,no significant difference was found(P>0.05)through statistical procedures,which indicated that the two groups were comparable.2.The curative effect ratio in two groups were compared: Notable effects in 11 patients,effective in 16 patients,ineffective in 3 patients,the total effective ratio was 90.00% in treatment group;notable effects in 1 patient,effective in 21 patients,ineffective in 8 patients,the total effective ratio was73.33% in control group.Compared the effective ratio of the two groups,significant difference was found(P<0.05),which indicated that the curative effect ratio of the treatment group was positive than that in control group.3.Comparison on clinical symptom integrals before and after intervention in two groups: compared the clinical symptom integrals before and after treatment between the two groups.Significant differences were found(P<0.05),which demonstrated that the clinical symptoms for both of the two groups were improved after intervention.Compared the symptoms of the two groups after intervention,significant difference was found(P<0.05),that indicated the curative effect ratio in treatment group was positive than that in control group.4.Comparison on the objective indicators on two groups before and after intervention: Compared the SIT,BUT and FLT integrals before and after the intervention on two groups,Significant differences were found(P<0.05),which indicated that this three indexes in both two groups were improved after intervention.The integrals of FLT,BUT and SIT were compared after treatment on two groups,significant differences were found(P<0.05),which indicated that the treatment group was better than control group on stabilizingof lacrimal membrane,increasing of secretion of tears and promoting of repair of corneal epithelium.Conclusions:1.The liver-regulating method has important guiding meaning on DE therapy,meanwhile,it provides new perspectives of differentiation and treatment.2.This study shows that the comprehensive treatment of DE by using liver-regulating methods of liver siothing,liver heat removing and liver nourishing can not only effectively relieve the symptoms of ocular surface symptoms,improve the level of SIT,BUT and FLT integrals,but also improve the general symptoms of patients.The curative effect is obviously better than simple Western medicine treatment,which reflecting the advantages of traditional Chinese medicine on treatments for DE.3.During the period of intervention,no serious adverse events in either group of patients.