The Correlation Between Hba1c Of Gestational Diabetes Mellitus In Middle And Advanced Stage And The Birth Weight And 6-week Physical Development Of Offspring

Objective This study was designed to investigate the association between different control targets of glycosylated hemoglobin in the third trimester of pregnancy and the development of offspring and 6 weeks of physical development in pregnant women with gestational diabetes.Methods A total of 556 pregnant women with gestational diabetes mellitus(GDM)and 600 pregnant women with normal glucose metabolism(NGT)were enrolled in our obstetrics outpatient clinic,endocrinology,and in our hospital from September 2016 to September 2018.All GDM pregnant women were given individualized lifestyle interventions,closely monitored blood glucose,failed blood glucose control,and monitored glycated hemoglobin every 4-6 weeks.The weight and length of the offspring of all the study subjects were collected,and the weight of the infants at 6 weeks was followed up to calculate the daily weight gain of the infants.1.Compare the differences in birth weight,body mass index,incidence of macrosomia,and daily weight gain at 6 weeks between GDM group and NGT group.2.To analyze the relationship between birth weight,macrosomia and mean HbA1 c in the GDM group.3.According to the average HbA1 c,the GDM components were divided into three subgroups,group A(220 cases): HbA1 c <5.5%,group B(256 cases): 5.5% ? HbA1c<6%,group C(80 cases): 6 % ? HbA1 c < 6.5%.The differences in neonatal birth weight,body mass index,incidence of macrosomia,and daily weight gain at 6 weeks between the three subgroups of GDM and NGT were compared.Results(1)Comparison of GDM group and NGT group: neonatal birth weight,body mass index,and incidence of macrosomia: GDM group was significantly higher than NGT group,the difference was statistically significant(p<0.05);every 6 weeks Daily weight gain: GDM group was significantly lower than NGT group,the difference was statistically significant(p<0.05).(2)The mean value of HbA1 c in GDM group was 5.5%±0.84;the birth weight ofGDM group and the middle and late pregnancy The mean HbA1 c was positively correlated(r=0.177,p=0.00).The best cut-off value of the average HbA1 c predictive size in the GDM group was 5.96%,sensitivity was 29.4%,specificity was 85.9%,and Yoden was analyzed by ROC curve analysis.The index was 0.153,and the area under the ROC curve was 0.561.(3)Stratification analysis: Compared with the three subgroups of GDM and NGT group,neonatal birth weight and body mass index were significantly higher in group C than in NGT group,group A and group B.There were statistical significance(p<0.05).There was no significant difference between the two groups in the NGT group,the A group and the B group(p>0.05).The incidence of giant children,group A,group B and C The group was significantly higher than the NGT group,the difference was statistically significant(p<0.05),and the C group was significantly higher than the A group and the B group.The difference was statistically significant(p<0.05).group B was slightly higher than group A,the difference was not statistically significant(p>0.05);daily weight gain at 6 weeks: group C was significantly lower than NGT group,group A and group B,the difference There were statistically significant differences(p<0.05).There was no significant difference between the two groups in the NGT group,the A group and the B group(p>0.05).Conclusions(1)Newborn birth weight and body mass index in the GDM group The incidence of macrosomia was significantly higher than that of the NGT group,and the growth rate of early infants was slower than that of the NGT group.(2)The birth weight,body mass index and the incidence of macrosomia in neonatal GDM pregnant women with an average HbA1 c ?6% in the middle and late pregnancy.Both increased significantly,and the early growth rate of infants was significantly slower.