Synthesis And Anticancer Activity Study Of Sulfonylated Furan And Imidazole Pyridine

Sulfonated heterocyclic compounds were one of the important families in heterocyclic compounds.Many pharmacologically molecules and natural products had the structure of Sulfonated heterocyclic compounds.And these compounds were widely employed in the fields of synthetically organic chemistry,medicinal chemistry and natural product chemistry.Among them,sulfonated furan derivatives and sulfonated imidazo[1,2-a]pyridine derivatives had wide application value in the pharmaceutical and chemical fields.In this paper,a multi-component reaction synthesis strategy was used to design and synthesize a variety of sulfonated furan derivatives and sulfonated imidazo[1,2-a]pyridine derivatives by high-efficiency and green chemistry methods.The details are as follows:In chapter 1,we introduce the application and research significance of furan derivatives and imidazo[1,2-a]pyridine derivatives and sulfonyl groups in drug molecular design,and their research progress.In chapter 2,a series of sulfonylated furan derivatives were synthesized by trifluoroacetic acid catalyzed reaction of 1,3-dicarbonyl compounds with phenylpropynyl aldehyde and sodium benzene sulfinate at room temperature.A plurality of sulfonylated furan derivatives having inhibitory activity against A549 cells were found by screening for anticancer activity.In chapter 3,a series of sulfonated imidazo[1,2-a]pyridine derivatives were synthesized by trifluoroacetic acid catalyzed reaction of 2-aminopyridine with phenylpropynyl aldehyde and sodium benzene sulfinate at room temperature.The products were screened for anticancer activity.