Study On The Relationship Between Polycystic Ovary Syndrome And Sleep Apnea Syndrome

Objective:Assess the risk for sleep apnea syndrome(SAS)in a group of women with polycystic ovary syndrome(PCOS)patients and healthy women.Explore the relationship between PCOS and SAS.Analyze the differences of sex hormone and glucose metabolism characteristics between PCOS patients with or without SAS.Methods:From January 2018 to February 2019,we recruited the 97 women with PCOS and 50 healthy women from the General Hospital of Tianjin Medical University.All of they completed the Epworth Sleepiness Scale and the modified Berlin questionnaire to assessment of SAS risk.BMI≧28kg/m~2 as the diagnostic criteria of obesity,analyze the risk of SAS risk between obese and non-obese PCOS patients and healthy women.All of them underwent sex hormone and OGTT and insulin.Result:1.The average ESS score was 10.20±2.90 in PCOS patients,while 7.64±3.12 in healthy women.PCOS patients had higher average ESS score than healthy women.,P<0.05,and the difference was statistically significant.The ESS score of≧9 was divided into ESS positive.Among the 97 PCOS patients,55 of them with ESS scores≥9,that is ESS positive rate in PCOS patients was 56.70%.Among the 50,only 19 of 50 healthy women with ESS scores≥9,the ESS positive rate in healthy women was 38%.The positive rate of ESS in PCOS patients was higher than that in healthy women,χ~2=4.616,P<0.05,the difference was statistically significant.2.In the result of BMQ,21 of 97 PCOS patients were positive in two or more parts of MBQ,the MBQ positive rate in PCOS patients was 21.65%.In healthy women,the MBQ positive rate in was 8%.The positive rate of MBQ in PCOS patients was higher than that in normal womenhealthy women,χ~2=4.355,P<0.05.The difference was statistically significant.3.The study subjects were divided into four groups:obesity PCOS patients(n=33,BMI≧28kg/m~2),non-obesity PCOS(n=64,BMI<28kg/m~2),obesity control women(n=10,BMI≧28kg/m~2)and non-obesity control women(n=40,BMI<28kg/m~2).In the non-obesity groups,the positive rate of PCOS patients in ESS and MBQ was higher than that in normal women,P<0.05,the difference was statistically significant.In the obesity groups,ESS positive rate and MBQ positive rate in PCOS patients and control women.There was no statistical difference,P>0.05.4.In non-obese PCOS patients,the testosterone is higher in ESS-positive patients than in ESS-negative patients P<0.05;Both in PCOS patients and healthy women,the ESS-positive is in higher fasting insulun and HOMA-IR than the ESS-negative P<0.05.5.With binary logistic regression analysis,BMI、fasting insulin、HOMA-IR and testosterone level were correlated with high risk of SAS in PCOS patients.Conclusion:1.The prevalence of PCOS patients with SAS is significant higher than the prevalence of normal people with SAS.It is necessary to screening SAS in PCOS patients to identify and alleviate related symptoms,such as snoring,waking unrefreshed from sleep,daytime sleepiness,and the potential for fatigue to contribute to mood disorders.2.In non-obese woman,the prevalence of PCOS patients with SAS is also significant higher than the prevalence of normal people with SAS.3.Compared with in PCOS patients without SAS,PCOS patients with SAS suffer more heavy insulin resistance.fasting insulin and HOMA-IR were correlated with high risk of SAS in PCOS patients.4.Compared with in PCOS patients without SAS,PCOS patients with SAS are in higher testosterone level.testosterone level.was correlated with high risk of SAS in PCOS patients.