Study On Differential Diagnosis Of Benign And Malignant Lung Lesions With Contrast-enhanced Ultrasonography

Part I Study on Differential Diagnosis of Benign and Malignant Lung Lesions with Quantitative Parameters of Contrast-enhanced UltrasonographyObjective:To evaluate the value of quantitative parameters of contrast-enhanced ultrasonography(CEUS)in differential diagnosis of benign and malignant lung lesions.Methods:50 cases of lung lesions diagnosed by puncture pathology were divided into benign group and malignant group,the quantitative parameters of CEUS time intensity curve(TIC)and the time difference of contrast agent to lung lesions and adjacent lung tissues were quantitatively analyzed.Results:1.In the quantitative parameters of TIC,the contrast agent arrive time(AT)in the benign group was less than that in the malignant group,and the difference was statistically significant between the two groups(P<0.05).There was no significant difference in the time to peak(TTP),the rise time(RT),the maximum intensity(IMAX)and the rising slope(RS)between the two groups(P> 0.05).2.Squamous cell carcinoma group and adenocarcinoma group were divided into malignant group.There was no significant difference in quantitative parameters of TIC between the two groups(P> 0.05).3.The time difference of contrast agent to lung lesions and adjacent lung tissues in the benign group was less than that in the malignant group,and the difference was statistically significant between the two groups(P<0.05).The optimal cut-off point of the time difference was 2.5s.Conclusion:1.The quantitative parameters of TIC have definite clinical value in the differential diagnosis of benign and malignant lung lesions.2.The time difference of contrast agent to lung lesions and adjacent lung tissues has certain value in the differential diagnosis of benign and malignant lung lesions.The time difference < 2.5 s indicates that the lesions tend to be benign,and the time difference > 2.5 s indicates that the lesions tend to be malignant.Part II A Preliminary Study of Contrast-enhanced Ultrasonography Mode in Benign and Malignant Lung LesionsObjective:To study the characteristics of contrast-enhanced ultrasonography in benign and malignant lung lesions,and to explore the value of contrast-enhanced ultrasonography in the differential diagnosis of benign and malignant lung lesions.Methods:50 cases of lung lesions diagnosed by pathology were divided into benign group and malignant group,the characteristics of contrast-enhanced ultrasonography were analyzed,including 23 cases in benign group and 27 cases in malignant group.Results:1.In benign group,the initial enhancement mode was more common in basal vessel type and peripheral type,accounting for 65.2% and 30.4%;In malignant group,the initial enhancement mode was more common in disorder vessel type,accounting for 37.1%,and the difference was statistically significant between the two groups(P<0.05).2.Squamous cell carcinoma group and adenocarcinoma group were divided into malignant group.In squamous cell carcinoma group,the initial enhancement mode was more common in disorder vessel type and local type,accounting for41.7% and 41.7%;In adenocarcinoma group,the initial enhancement mode was more common in peripheral type,accounting for 50.0%,and the difference was statistically significant between the two groups(P<0.05).Conclusion:Contrast-enhanced Ultrasonography of benign and malignant lung lesions has certain characteristics,which is helpful to the differential diagnosis of benign and malignant lung lesions.