Analysis Of The Correlation Between Helicobacter Pylori Infection And Ulcerative Colitis

Objective: Investigate the relationship between helicobacter pylori(Hp)and the ulcerative colitis(UC)patients infected by helicobacter pylori.Methods: All the patients were enrolled in Qingdao City Hospital.Date from 2007.01 to 2017.06.A total of 146 patients with UC who underwent endoscopy and pathology were accepted.It included 63 males and 83 females with an average age of(53.6±12.5)years.At the same time,150 cases of physical examination with no obvious colonic lesions under electronic colonoscopy were collected as control group.The group included 64 males and 86 females,with an average age of(51.3±11.2)years old.There was no significant difference in the general data such as gender and age between the two groups.According to the range of endoscopic lesions,the UC patients were divided into rectal type,left half colon type and wide colon type by using Montreal classification.According to the histological examination of mucosal biopsy,the UC group was divided into active stage and remission stage.All individuals in UC group were graded according to the Southerland disease activity index(DAI)score: scored 0-3 according to the severity of diarrhea,blood in the stool,mucosal manifestations and physician's assessment of the condition.A total score of ?2 was classified as symptoms alleviated,3-5 was classified as mild activity,6-10 was classified as moderate activity,and 11-12 was classified as severe activity.The infection of Hp detected by rapid urease test and histopathological biopsy in the two groups was analyzed retrospectively.The infection of Hp in different lesion areas in UC group was compared,and the incidence of Hp infection in different active stages and remission stage was compared.Results: There were 146 patients in UC group.There were 27 positive and the positive rate of Hp infection was 18.49%.In 150 cases of control group,there were 64 positive,and the positive rate of Hp infection was 42.67%.The UC group was significantly lower than the control group.The result showed statistical significance(P <0.05).By lesion range: 27 cases in the rectal group,7 cases were positive,Hp positive rate was 21.88%,48 cases in the left colon group,9 cases were positive,Hp positive rate was 18.75%,66 cases were extensive colon group,11 cases were positive and the Hp positive rate was 16.67%.There was no significant difference among the three groups(P>0.05).In UC group,there was no significant difference in the infection rate of Helicobacter pylori regardless of the size of the lesion.There were 29 patients at remission stage(19.86%)in the UC group,11 patients were positive,the positive rate of Hp infection was 37.93%,and 117 patients(80.14%)were active,including 64 patients with mild active period and 11 cases were positive,the positive rate of Hp infection was 17.19%;37 cases of moderate active period,4 cases were positive,the positive rate of Hp infection was 10.81%;16 cases of severe active period,1 case was positive,the positive rate of Hp infection was 6.25%.The positive rate of Hp infection in different active stages and remission stage of the disease was different,P < 0.05,the difference was statistically significant.The remission period was compared with the mild,moderate,and severe activity period,the P values were all <0.05,and the differences were statistically significant.That was to say,as long as UC patients were in active stage,no matter their illness was mild,moderate or severe,there was a difference in the infection rate of Helicobacter pylori compared with that in remission stage,and there was statistical significance.The comparison among the mild,moderate,and severe active period showed that the P values were all >0.05,and the differences were not statistically significant.The infection rate of Helicobacter pylori in UC patients showed no significant difference with the increase of disease activity.Conclusion: There is a negative correlation between Helicobacter pylori infection and ulcerative colitis.Helicobacter pylori may be a protective factor for ulcerative colitis and may prevent the development of ulcerative colitis.Strengthening the follow-up of patients with ulcerative colitis can effectively reduce the risk of cancerous ulcerative colitis.Significance: Ulcerative colitis(UC)is a common gastrointestinal disease in adults.It is a chronic inflammation and debilitating disease that mainly affects the colonic mucosa and submucosa.Ulcerative colitis is commonly occured in patients between the ages of 50 and 60 years.The etiology of UC is not completely unknown yet.However,excessive stimulation causes metabolic disorders of the mucosal immune system,which seems to be a major pathophysiological pathway.These reactions may also be responses to the bacterial changes within the colon itself.Helicobacter pylori is one of the major factors that leading to inflammation of the stomach and duodenal ulcer.Helicobacter pylori produce a variety of enzymes that include harmful enzymes such as urease,catalase,protease,lipase and phospholipase,etc.These enzymes may participate in the pathogenesis of gastritis through several pathways.At the same time,the metabolites produced by Helicobacter pylori may enter the intestines.Epidemiological data show that Inflammatory bowel disease(IBD)is more prevalent in areas with low Helicobacter pylori infection rates and suggests that Helicobacter pylori infection may have protective effects on IBD and certain autoimmune components.Through further investigation and research,we hope to explore the specific links between the two things.Besides,we may provide a new experimental basis for clinical research.