Investigation And Analysis Of Iodine Intake And Thyroid Disease In Hebei Province

Object: In order to understand the iodine intake and prevalence of thyroid diseases in hebei region,and to compare the differences of iodine intake levels between urban and rural areas,gender and different age groups,and to explore the relationship between iodine intake and thyroid diseases in hebei region,a more powerful theoretical basis was provided for the recommendation of iodine intake in hebei region.Methods:This study,multi-stage stratified cluster random sampling,in hebei region lived more than 5 years,2650 permanent residents over the age of 18,city survey population 1393,1257 rural people,all agreed to participate in the project of respondents fill out the informed consent,take the field population register,fill out the questionnaire,the perfect physical examination(height,weight,blood pressure,waist circumference),taking blood samples determination of thyroid function(TSH,TPOAb,TGAb,FT4,FT3),to return the morning urine determination of urine iodine(UI),preliminary thyroid touch,To improve thyroid ultrasonography and other examinations,and input the flow data of all the participants into the database for statistical data analysis.Results:1.The MUI of adults in hebei was 210.05?g/L,indicating that the iodine intake of adults in hebei was in excess of iodine level.Male MUI was 210.3?g/L,female MUI was 192.5?g/L,and the MUI between the genders in hebei region was statistically significant(P<0.05).Urban MUI was 188.7?g/L,and rural MUI was 214.4?g/L.The comparison of urban and rural MUI in hebei region was of statistical significance(P<0.05).Among the six groups,there was statistical significance between the ages of 18-29 and the other groups(P<0.05).The ages of 18-29 were iodine overdose levels,and the other ages were iodine appropriate levels.2.The prevalence of thyroid diseases:Clinical hyperthyroidism(0.41%),subclinical hyperthyroidism(0.41%),clinical hypothyroidism(0.79%),subclinical hypothyroidism(9.96%),Hashimoto's thyroiditis(4.04%),simple goiter(0.53%).Nodular goiter(0.04%),single thyroid nodules(9.32%),multiple thyroid nodules(5.36%),Thyroid cancer(0.08%).There was no statistical significance between urban and rural areas and gender between single thyroid nodules and multiple thyroid nodules in hebei region.3.According to the flow survey data in this study,there was no statistically significant difference in TSH among different iodine intake levels in hebei.The difference of TPOAb positive rate between different iodine intake levels was statistically significant(P< 0.05).There were statistically significant differences in the positive rates of TGAb and TPOAb at different iodine intake levels(P< 0.05).The TPOAb positive rate,TPOAb positive rate and TGAb positive rate were statistically significant between different groups(P < 0.05).Further pairwise comparison(Iodine deficiency group,iodine amount group,iodine excess group,iodine excess group)showed that in the TPOAb positive rate group,there was statistically significant difference between the iodine deficiency group and the iodine excess group(P< 0.05);in the TPOAb and TGAb positive rate groups,there was statistically significant difference between the iodine deficiency group and the iodine excess group(P< 0.05).4.There was no statistically significant difference between different iodine intake levels and thyroid disease groups in hebei region.Conclusion:1.The iodine nutritional status in Hebei is at the level of iodine excess.The urinary iodine level in rural areas is higher than the urban urinary iodine level.The urinary iodine level of males is higher than that of female urinary iodine.2.The prevalence of thyroid nodules in Hebei was 14.68%,and there was no significant difference in the thyroid nodules and thyroid multiple nodules between urban and rural areas.3.The iodine deficiency group in Hebei increased the positive rate of TPOAb and TGAb,and the difference mainly existed between iodine deficiency group and iodine excess group.4.There was no significant difference in the iodine nutritional status between the various thyroid disease groups.