The Efficacy And Safety Of Transcutaneous Electrical Acupoint Stimulation Anesthesia In The Oocyte Retrieval Of IVF-ET

Objective:This essay aims to evaluate the efficacy and safety of transcutaneous acupoint electrical stimulation in anesthesia during oocyte retrieval of in vitro fertilization-embryo transfer(IVF-ET),by comparing the effects of anesthesia and prevention of postoperative nausea and vomit of transcutaneous acupoint electrical stimulation(experimental group),the placebo transcutaneous acupoint electrical stimulation(placebo group)and diclofenac sodium analgesic suppository(drug control group)in oocyte retrieval.Methods:Experiment subjects are 108 patients who underwent IVF/ICSI-ET treatment in the Reproductive Center of Renmin Hospital of Wuhan University from January to August in 2018(The number of follicles with diameter greater than or equal to 14 mm was 5-15).The basic data of the patients were collected according to the decisions of both patients and doctors.The patients were divided into experimental group(n=43),placebo group(n=20)and drug control group(n=45).Different interventions were given 30 min before operation.The experimental group was given TEAS 2/100 Hz,10-20 m A electrical stimulation(continuously),the placebo group was given TEAS 2 Hz,2 m A electrical stimulation(set to work for 3 seconds,stop for 6 seconds),and the drug control group was given diclofenac sodium suppository 100 mg plug anal.PRI,VAS,PPI,nausea and vomiting scores were evaluated after oocyte retrieval.Subjective validity evaluation was performed on the patients in the experimental group and the placebo group.After three days of follow-up and observation,conclusion about the oocyte retrieval rate,2PN fertilization rate,2PN cleavage rate and high-quality embryo rate can be drawn.Results:(1)The VAS scores of the experimental group were lower than those of the control group and the drug control group(P<0.05;P<0.001).At the same time,the PRI score and PPI score of the experimental group were lower than those of the drug control group(P < 0.001,P < 0.05),the PRI score of the placebo group was lower than the drug control group(P <0.05);(2)The nausea score of the experimental group was lower than that of the control group(P<0.05),but there was no significant difference compared with the drug control group(P>0.05).There was no vomiting after oocyte retrieval in the three groups;(3)There was no difference in the subjective validity between the experimental group and the placebo group(P>0.05);(4)There was no significant difference in the oocyte retrieval rate,2PN fertilization rate,2PN cleavage rate and high-quality embryo rate among the three groups(P>0.05).Conclusion:(1)In IVF-ET oocyte retrieval,the analgesic effect of transcutaneous acupoint electrical stimulation was significantly better than that of placebo transcutaneous acupoint electrical stimulation and diclofenac sodium analgesic suppository,confirming the effectiveness of transcutaneous acupoint electrical stimulation analgesia;(2)The setting of the comfort group is scientific and reasonable;and the analgesic effect is not the psychological effect of the patient;(3)The application of transcutaneous acupoint electrical stimulation in oocyte retrieval analgesia has certain safety and has no effect on IVF-ET embryo culture outcome.To ensure no effect on IVF-ET outcome,the sample size should continue to be increased.Further follow-up of the outcome of clinical pregnancy is also necessary;(4)Transcutaneous acupoint electrical stimulation can be applied to clinical oocyte retrieval analgesia as a routine analgesic method.