Relationship Between MP-DNA In Sputum And Clinical Manifestations Of Mycoplasma Pneumoniae Pneumonia In Children

Objective:To explore the relationship between Mycoplasma pneumoniae(MP)-DNA in sputum and clinical manifestations in children with Mycoplasma pneumoniae pneumonia(MPP).Methods:Choose chidrens diagnosed Mycoplasma pneumoniae pneumonia in Children’s hospital of chongqing medical university from January 2015 to August 2018 as the research object,according to the MP-DNA,we divide the children into 2 groups:group of low MP load(MP-DNA is less than or equal to 10~6/mL),and group of high MP load(MP-DNA is more than 10~6/mL),analyze the differences of this two groups from the following aspects:basic information,clinical manifestations,course of the disease,laboratory tests,imaging findings,pulmonary function and extrapulmonary complications.Results:The course of the disease and the duration of fever time of the children in high MP load group are longer than that of the children in group of low MP load(P=0.000,P=0.000),and the thermal peak is higher(P=0.003).The incidence of severe pneumonia in high MP load is higher(P=0.000),there was no difference in the proportion of patients with recurrent fever after treatment with azithromycin for 3 days and 7 days(P=0.814,0.177),but some children who still have fever after treatment of azithromycin for 7days are stopped febrile within 24 hours after hormone therapy.Among the blood test indexes,D dimer is higher in the children in high MP load group(P=0.028),while there is no statistical difference in other blood test indexes.Imaging examination shows that the incidence of pulmonary atelectasis or pulmonary consolidation and pleural effusion are higher in high MP load chidren(P=0.010,0.011).And cardiac complication and overall extrapulmonary complications are more common in children from group high MP load than low load(P=0.021,0.002).In terms of lung function,the measured/predicted values of FVC and V75 in children in high load are lower than that in children in group of low load(P=0.033,0.014).Conclusion:SputumMP-DNA isassociatedwithclinical manifestations in children with mycoplasma pneumonia.Children with higher copy number have longer heat course and disease duration,higher heat peak and higher incidence of pulmonary atelectasis or pulmonary consolidation and pleural effusion and extrapulmonary complications,and the pulmonary ventilation function and coagulation function are susceptible.However,there is no significant relationship between the copy number and fever time after treatment with azithromycin,because of the influence of immune response,so the condition of children cannot be judged solely on the basis of copy number,but should be analyzed together with the immune response of children.