Study On The Correlation Between PR And BMP2 In Decidual Membrane Of Elderly Pregnant Women

Objective:To investigate the effect of progesterone receptor and BMP2 on adverse pregnancy in old age by detecting the differences of progesterone receptor and BMP2 expression in decidual tissues of old and young pregnant women.Methods:From January 2018 to June 2018,a total of 141 pregnant women were selected to give birth in the maternity ward of the first affiliated hospital of hunan normal university,including 88 young pregnant women and 53 elderly pregnant women,including natural childbirth and cesarean section.There were 70 cases in the young normal pregnancy outcome group,24 cases in the old normal pregnancy outcome group,18 cases in the young adverse pregnancy outcome group,and 29 cases in the old adverse pregnancy outcome group.Immunohistochemical methods were used to detect the expression levels of progesterone receptor and BMP2 in decidual tissues of pregnant women in each group,and statistical analysis was performed.Results:1.88 young pregnant women and 53 old pregnant women showed no statistical difference in pregnancy and delivery times(P > 0.05),and there was a statistical difference in pregnancy weeks(P < 0.05).2.Comparison of progesterone receptor expression levels in decidua tissues:(1)progesterone receptor expression level in the young normal pregnancy outcome group was higher than that in the old normal pregnancy outcome group,and the difference was statistically significant(P < 0.05);(2)The expression level of progesterone receptor in the young normal pregnancy outcome group was higher than that in the young adverse pregnancy outcome group,but the difference was not statistically significant(P > 0.05).(3)The expression level of progesterone receptor in the old normal pregnancy outcome group was higher than that in the old adverse pregnancy outcome group,but the difference was not statistically significant(P > 0.05).(4)The level of progesterone receptor in the young adverse pregnancy outcome group was higher than that in the old adverse pregnancy outcome group,and the difference was statistically significant(P < 0.05).(5)The expression level of progesterone receptor in the normal pregnancy outcome group was higher than that in the adverse pregnancy outcome group,and the difference was statistically significant(P < 0.05).3.Comparison of BMP2 expression level in decidual tissues:(1)the expression level of BMP2 in the young normal pregnancy outcome group was higher than that in the old normal pregnancy outcome group,and the difference was statistically significant(P < 0.05);(2)The expression level of BMP2 in the young normal pregnancy outcome group was higher thanthat in the young adverse pregnancy outcome group,but the difference was not statistically significant(P > 0.05).(3)The expression level of BMP2 in the old normal pregnancy outcome group was higher than that in the old adverse pregnancy outcome group,but the difference was not statistically significant(P>0.05).(4)The expression level of BMP2 in the young adverse pregnancy outcome group was higher than that in the old adverse pregnancy outcome group,and the difference was statistically significant(P < 0.05).(5)The expression level of BMP2 in the normal pregnancy outcome group was higher than that in the adverse pregnancy outcome group,and the difference was statistically significant(P < 0.05).4.Correlation analysis:(1)there was a positive correlation between progesterone receptor and BMP2 expression level in decidual tissue of141 pregnant women(r = 0.865,P<0.05).(2)In 94 cases of normal pregnancy outcomes,there was a positive correlation between progesterone receptor and BMP2 expression in decidual tissue of pregnant women(r = 0.870,P < 0.05).(3)In 47 cases of adverse pregnancy outcomes,progesterone receptors in decidual tissues of pregnant women were positively correlated with BMP2 expression(r = 0.852,P < 0.05).Conclusion:1.Progesterone receptor and BMP2 expression levels were correlated with age.2.Progesterone receptor and BMP2 expression levels were associatedwith adverse pregnancy.3.In human endometrial deciduation,progesterone receptor expression has a synergistic effect with BMP2 expression.