| Objective To investigate the mechanism of Weixihuaji decoction in the treatment of gastric polyps by conducting a randomized controlled clinical study of Weixihuaji decoction in the prevention and treatment of gastric polyps,and to confirm that Weixihuaji decoction has a definite effect on the recurrence and treatment of gastric polyps,and to clarify the effect of Weixihuaji decoction on epidermal growth factor(EGF)and epidermal growth factor receptor(EGFR)in gastric mucosa.Methods From January 2015 to December 2017,60 patients with gastric polyps were selected according to inclusion criteria and exclusion criteria in two hospitals of Inner Mongolia Traditional Chinese Medicine Hospital and the Affiliated Hospital of Inner Mongolia Medical University.A randomized parallel controlled study was conducted.Each hospital(center)with gastric polyps of weakness of the spleen and stomach and phlegm and blood stasis syndrome was randomly divided into two groups according to 1:1 after endoscopic resection.The control group was given conventional western medicine treatment according to the protocol.The treatment group was treated with Weixihuaji Decoction,once daily for 4 weeks.The gastroscope and biopsy were re-examined 6 months after drug withdrawal,and the results were observed.TCM symptom score,histopathological efficacy,eradication rate of Helicobacter pylori(Hp),and changes of gastric mucosal EGF and EGFR were compared between the two groups before treatment and 4 weeks,8 weeks and 6months after treatment.And the two groups of conventional indicators and safety indicators were compared and evaluated.Results1.TCM syndrome improvement efficacy: the experimental group compared with the western medicine routine control group syndrome improvement efficacy,the experimental group improved TCM syndrome efficacy than the control group,the difference was statistically significant(P < 0.05);the total effective rate of the experimental group was better than the control group,the difference was statistically significant(P < 0.05).2.Improvement of the total score of TCM syndrome: The total score of each group before and after treatment was compared between the Weixihuaji decoction group and the western medicine routine group,and the results of both groups were effective,and the difference was statistically significant(P < 0.05);the two groups were compared at 4 weeks,8 weeks,and 6 months after the treatment was stopped,respectively,and the Weixihuaji decoction group was superior to the western medicine routine group,and the differences were statistically significant(P < 0.05).3.Mucosal color and vascular permeability of gastroscope phase: Before and after treatment in the test group and after treatment in the two groups,compared with the western medicine routine group,the difference was statistically significant(P < 0.05);within the control group before and after treatment,the difference was not statistically significant(P > 0.05).Mucosal folds and mucosal texture: There was no significant difference between the test group and the control group before and after treatment(P > 0.05);there was significant difference between the two groups after treatment(P< 0.05).4.Pathological score inflammation: There was statistically significant difference between the test group and the control group before and after treatment(P < 0.05);atrophy: there was statistically significant difference between the test group before and after treatment(P < 0.05),and between the control group before and after treatment(P > 0.05).Intestinal metaplasia and dysplasia: There was no significant difference between the test group and the control group before and after treatment(P > 0.05).5.Hp eradication: After treatment,the Hp positive infection was compared between the two groups,and the test group was superior to the control group,and thedifference had statistical significance(P < 0.05);after treatment,the Hp eradication rate was compared between the two groups,and the Wei Shi Hua Ji Tang group was significantly superior to the western medicine routine group,and the difference had statistical significance(P < 0.05).The test group had good efficacy in eradicating Hp.6.Expression of EGF and EGFR: There was significant difference between the two groups before and after treatment(P < 0.05).There was no significant difference between the control group before and after EGF and EGFR treatment(P > 0.05).After treatment,EGF and EGFR in the two groups were better than those in the conventional group,and the differences were statistically significant(P < 0.05).7.Recurrence of polyps: After treatment,the recurrence rate of polyps in the two groups was compared,and the recurrence rate in the Weixihuaji decoction group was significantly lower than that in the conventional western medicine group,and the difference was statistically significant(P < 0.05).Conclusion Weixihuaji decoction is effective in improving TCM syndrome,gastric mucosal color,vascular penetration,histopathological inflammation,atrophy,Hp eradication rate,gastric mucosal EGF,EGFR expression,polyp recurrence in patients with gastric polyps.The combination of Weixihuaji decoction and conventional western medicine in the treatment of patients with gastric polyps with weak spleen and stomach and phlegm and blood stasis can effectively relieve their clinical symptoms,improve the pathological state of gastric mucosa,eradicate HP,and may prevent the occurrence of gastric polyps by decreasing the expression of EFG and EGFR in gastric mucosa. |
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