Clinical Significance Of Changes In The Levels Of Pentraxin3 (PTX3) And Chemokine 16 (CXCL16) In Acute Coronary Syndrome

Objective Changes in the expression levels of plasma PTX3(Pentraxin3),CXCL16(Chemokine16)and ox-LDL(Oxidized low density lipoprotein)in patients with coronary heart disease correlation analysis of plaque stability and coronary artery stenosis,further explore the clinical significance of cytokines in the short-term prognosis of patients with acute coronary syndrome.Methods From May 2017 to June 2018,160 patients with coronary heart disease were diagnosed by coronary angiography in our hospital,and 40 normal coronary angiography were collected as control group.The basic data of the selected patients were collected,and the patients with acute coronary syndrome(120 cases)who underwent successful percutaneous coronary angioplasty(PCI)were collected for the next day and 1 month after surgery.Plasma PTX3,CXCL16,and ox-LDL concentrations were measured by immunoassay(Enzyme-linked immunosorbent assay,ELISA).hs-CRP was measured by AHCL-XT-005 specific protein analyzer.The severity of coronary lesions was judged by Gensini score,and the postoperative patients were followed.After half a year of follow-up,major adverse cardiac events(MACE)were observed: recurrent angina,recurrent myocardial infarction,heart failure,and malignant arrhythmia.According to the follow-up results,they were divided into MACE group and no MACE group.Results(1)The levels of plasma PTX3,CXCL16,and ox-LDL in the patients with acute coronary syndrome(120 cases)were significantly higher than those in the stable angina group(40 cases)and the control group(40 cases).The levels of plasma PTX3,CXCL16 and ox-LDL in 60 patients were higher than those in unstable angina pectoris(60 patients),and the difference was statistically significant(P<0.05).(2)The levels of PTX3 and CXCL16 in the patients with acute coronary syndrome were significantly higher than those before surgery.The levels of PTX3 and CXCL16 weresignificantly lower than those of preoperative factors in January.The difference was statistically significant(P <0.01).(3)Pearson linear correlation analysis showed that PTX3 was positively correlated with ox-LDL,hs-CRP and Gensini scores(r=0.886,P<0.01;r=0.762,P<0.01;r=0.346,P<0.01);CXCL16 and The ox-LDL,hs-CRP and Gensini scores were positively correlated(r=0.959,P<0.01;r=0.656,P<0.01;r=0.339,P<0.01).(4)The levels of plasma PTX3 and CXCL16 in the MACE group were significantly higher than those in the non-MACE group at 1 month after operation(P<0.05),and Logistic regression analysis indicated that PTX3 was more valuable for the recent prediction of MACE.Conclusion Plasma PTX3,CXCL16,and ox-LDL can be used as early biomarkers of acute coronary syndrome,which are related to the stability of plaque and the degree of lesions.Simultaneous multi-factor detection can greatly improve the early diagnosis rate of the disease.It also has a positive effect on the patient's recent prediction of MACE.