Correlation Between Non-high-density Lipoprotein Cholesterol Level And Gensini Score In The Patients With Coronary Heart Disease

Objective To investigate the connection and clinical significance between non-high-density lipoprotein cholesterol level(non-HDL-C) and Gensini score in the patients with coronary heart disease(CHD).Methods We choosed thepatients of 225 cases who were suspected of coronary artery disease as research subjects in the Department of Cardiology of the First Affiliated Hospital of Anhui Medical University during August 2014 to July 2015. After relevant examination, those subjects were performed an operation of coronary angiography(CAG), with 39 cases of CAG-negative as healthy controlgroup(HC group) and 186 cases of CAG- positive as CHD patients, and the latter were further divided into two subgroups, angina pectoris group(AP group) with 122 cases and acute myocardial infarction group(AMI group) with 64 cases according to the clinical characteristics. Furthermore, the low non-HDL-C subgroup of 21 cases and high non-HDL-C subgroup of 32 cases were classified among the patients whose low-density lipoprotein cholesterol(LDL-C) were controlled less than 1.80 mmol / L in AP group. While we collected research subjects’ medical information, including age, sex, blood pressure, routine blood, fasting plasma glucose(FPG), creatine kinase-MB isoenzyme(CK-MB), cardiac troponin I(c Tn I), creatinine(Cre), total cholesterol(TC), triglyceride(TG), high density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C) levels and reccorded the history of taking lipid-lowering drugs, hypertension, diabetes, smoking.Results1.The level of non-HDL-C in AMI group was higher than that in AP group and HC group(mean ± SD,3.72±0.89mmol/L vs. 3.36±0.92mmol/L vs. 2.82±0.61mmol/L), the level of non-HDL-C in AP group was higher than that in HC group(mean ± SD,3.36±0.92mmol/L vs. 2.82±0.61mmol/L)(P<0.05). 2.The level of LDL-C in AMI group was higher than that in AP group and HC group(mean ± SD,3.35±0.80mmol/L vs. 2.92±0.79mmol/L vs. 2.58±0.53mmol/L), the level of LDL-C in AP group was higher than that in HC group(mean ± SD,2.92±0.79mmol/L vs. 2.58±0.53mmol/L)(P<0.05). 3.The level of Gensini score in AMI group was higher than that in AP group and HC group(mean ± SD,90.1±48.18 分 vs. 36.15±30.02 分 vs. 1.51±2.94 分), the level of Gensini score in AP group was higher than that in HC group(mean ± SD,36.15±30.02 分 vs. 1.51±2.94 分)(P<0.05). 4.The level of Gensini score in CHD patients including AP group and AMI group was positively correlated with non-HDL-C(r = 0.562, P <0.05) and LDL-C(r = 0.327, P <0.05), andwas negatively with HDL-C(r =-0.259, P <0.05). 5.The patients with LDL-Cless than 1.80 mmol / L in AP group, the non-HDL-C level in high subgroup(≥2.6 mmol / L) was significantly increased compared with the non-HDL-C level in low subgroup(<2.6 mmol / L) in terms of the Gensini score(mean ± SD,37.71±8.36 分 vs. 26.32±13.41 分)(P<0.05).Conclusion 1.The level of LDL-C in patients with coronary heart disease is higher than that of normal population, and so is the non-HDL-C’level. The level of non-HDL-C in Plasma is closely related to Gensini score which can reflect the severity of coronary artery lesions.. 2.Based on the level of LDL-C less than 1.80 mmol/L with drugs,the patients of angina pectoris whose non-HDL-C level are higher have greater Gensini score and moreserious coronary artery lesions. Thus, the non-HDL-C’level in patients with LDL-C well controlled,may be a new indicator of cardiovascular residual risk.