Preliminary Study On The Relationship Between Chronic Inflammation And Biopsy Results In Prostate Biopsy

Objective: To investigate the effect of histological inflammation in prostate biopsy on prostate biopsy results in men with elevated serum prostate specific antigen(PSA).Methods:A total of 771 patients with serum PSA levels of 4-50 ng / mL were enrolled in the study.All patients underwent perineal prostate biopsy.A retrospective analysis of the biopsy results of the included patients was performed to assess the relationship between chronic inflammation in the biopsy results,high-grade prostatic intraepithelial neoplasia,and prostate cancer.A retrospective analysis of the non-malignant group of biopsy results revealed that 30 patients underwent repeated puncture and evaluated the predictive effect of chronic inflammation on the first biopsy based on repeated puncture results.Results:Of the 771 needle biopsy patients,354 were diagnosed with prostate cancer(PCa group)and 332 were diagnosed with benign prostate tissue(BPD group),and high-grade prostatic intraepithelial neoplasia(HGPIN group)was 85.A total of 420 chronic inflammation.The prostate volume and transition volume in the PCa group and the Hgipn group were significantly smaller than those in the BPD group,and serum PSA levels and PSA density(PSAD)were significantly higher than those in the BPD group.There was a significant difference in the incidence of histological inflammation between the PCa(41%),Hgipn group(15%)and the BPD(79%)group.Chronic inflammation was independently and negatively correlated with PCA and HGPIN: OR was 0.80,0.11,and PSAD was positively correlated with PCA and HGPIN: OR 22.71,15.20,respectively.According to the biopsy results of Gleason and chronic inflammatory frequency distribution(?2,p<0.05),chronic inflammatory infiltration may be negatively correlated with higher-grade tumors.In 30 repeat biopsy groups,biopsy positive 9,initial inflammation with 3,no inflammation,6 negative,21 initial inflammation with 5,no inflammation 5,the first biopsy chronic inflammation and repeated biopsy results were significantly negatively correlated,P < 0.05.As with the first biopsy,we only found that PSAD and chronic inflammation were independent risk factors for repeated biopsy results.In addition,in the repeated biopsy,considering the PSAD and the first biopsy of chronic histological inflammation,it can be predicted that the positive and negative biopsy were 8 and 22,respectively.Of the 8 cases,6 found PCa in biopsy specimens,and 19 of 22 negative patients did not find Pca after biopsy.Therefore,the sensitivity,specificity,positive predictive value and negative predictive value of predictive repeat biopsy were 66.7%,90.4%,75% and 86.3%.Conclusion: Chronic inflammation is less common in prostate cancer and high-grade intraepithelial neoplasia(HGPIN).These observations suggest that inflammation may protect the body and reduce the incidence of subsequent PCa.PSAD and chronic histological inflammation are independently associated with PCa.After initial biopsy,patients with elevated serum PSA levels can be predicted using histological inflammation and PSAD to screen out the best patients for repeated punctures to avoid unnecessary duplication puncture.