Analysis Of Related Factors Of Nerve Function Defect In Acute Cerebral Infarction

Purpose:To explore the relationship between the related factors and the degree of neurological defects in acute cerebral infarction,and to provide a clinical basis for the prevention and treatment of acute cerebral infarction.Methods: From January 2017 to December 2018,a total of 307 patients with acute cerebral infarction and met the inclusion criteria(the onset time was confirmed within 72 hours by head CT and/or magnetic resonance imaging,and it was the first onset)admitted to the fourth neurology ward of the fourth hospital of China medical university were counted.Patients' gender,age,smoking history,drinking history and previous history of hypertension,diabetes,myocardial infarction and atrial fibrillation were recorded in detail.Imaging findings included carotid ultrasound and lung CT.Serum test results(the second day after admission)included triglycerides,total cholesterol,high-density lipoprotein,low-density lipoprotein,glycosylated hemoglobin,serum uric acid,homocysteine,d-dimer,and fibrinogen.Among them,mean±standard deviation(`X±S)was used to represent the measurement data.Count data are represented by examples(percentages).NIHSS score was used to evaluate the degree of neurological impairment in patients with acute cerebral infarction,and to explore the relationship between the relevant factors and the degree of neurological impairment in patients with acute cerebral infarction.First,univariate analysis was used to analyze the correlation between the relevant factors in patients with acute cerebral infarction and the degree of neurological impairment.Then,the factors with statistical significance in univariate analysis were included in the multivariate ordered Logistic regression analysis.Finally,the correlation between other factors and the positive results of multivariate regression analysis was discussed.Among them,Student's t test was used for measurement data,c(17)test was used for count data,Pearson correlation test was used for linear correlation test,and linear regression analysis was performed for significant factors.Test level ?=0.05,P<0.05 was considered statistically significant.Results:1.The single factor analysis showed that age,a history of atrial fibrillation in patients with acute cerebral infarction and carotid atherosclerosis plaque formation,merging,pneumonia,blood,blood homocysteine d-dimer,blood fibrinogen in the patients with mild,moderate and severe group the difference was statistically significant(P = 0.009,P = 0.005,P = 0.000,P = 0.006,P = 0.026,P = 0.000,P = 0.008).The above factors were included in the multivariate ordered Logistic regression analysis,and the results showed that patients with blood d-dimer(OR=1.002,95%CI:1.001-1.004,P=0.007),history of atrial fibrillation(OR=2.643,95%CI:1.207-5.789,P=0.015),and complicated pneumonia(OR=2.321,95%CI:1.223-4.406,P=0.010)was statistically significant in patients with mild,moderate or severe cerebral infarction,and the differences in blood d-dimer(OR=1.002,95% CI:1.001-1.004,P=0.007)were statistically significant in patients with acute cerebral infarction.2.The acute cerebral infarction patients' gender,age,smoking history,history of heavy drinking,history of atrial fibrillation,merging,pneumonia,blood triglycerides,glycosylated hemoglobin,blood fibrinogen and blood d-dimer level has a relationship(Among them,gender,history of smoking,history of excessive drinking,history of atrial fibrillation,and pneumonia were included in the measurement data,the correlation of Student's t test were P = 0.005,P = 0.034,P = 0.007,P = 0.010,P = 0.000.Age,blood triglycerides,glycosylated hemoglobin,and fibrinogen were included in the count data,the correlation of Pearson test significance were P=0.000,P=0.002,P=0.007,P=0.002,linear regression analysis r=0.501,r=-0.178,r=-0.153,r=0.179).Conclusion:1.High d-dimer level,history of atrial fibrillation and associated pneumonia are correlated with the degree of neurological impairment in acute cerebral infarction,suggesting that these factors may aggravate the degree of neurological impairment.2.Gender,age,history of smoking,history of excessive drinking,history of atrial fibrillation,combined pneumonia,blood triglycerides,glycosylated hemoglobin,and fibrinogen are correlated with blood d-dimer level in patients with acute cerebral infarction,suggesting that these factors may aggravate the degree of neurological impairment by increasing blood d-dimer level.