Clinical Observation On Treatment Of Kidney Deficiency And Blood Stasis Type Of Luteal Insufficiency Infertility By Bushen Huoxue Sequential Therapy

Objective:According to TCM syndrome differentiation,patients with kidney deficiency and blood stasis type luteal insufficiency infertility were treated with traditional Chinese medicine for tonifying kidney and promoting blood circulation.The pregnancy rate,TCM syndrome score,serum progesterone(P)level and endometrium were observed before and after treatment.Thickness,basal body temperature(BBT)type and BBT high temperature phase score(HPS),etc,to evaluate the clinical efficacy of Bushen Huoxue Sequential Therapy in the treatment of patients with kidney deficiency and blood stasis type luteal insufficiency infertility.Methods:Sixty patients with luteal insufficiency infertility with kidney deficiency and blood stasis were collected and randomly divided into the treatment group and the control group,30 patients in each group.For more than six consecutive months follow-up,in patients with complete clinical observation table,records in the two groups before and after treatment in patients with pregnancy situation,Chinese medicine symptom integral,BBT type and HPS,middle luteal serum P values and endometrial thickness,etc.,using statistical analysis,observation of kidney invigorate the sequential therapy in treating kidney and blood stasis type of corpus luteum insufficiency of sterility of curative effect.Results:1.Before treatment,there were no statistically significant differences between the two groups in age distribution,course of disease,infertility type,TCM symptom score,BBT type and HPS,serum P level in the middle luteal stage and endometrial thickness(P > 0.05),which was comparable.2.In terms of pregnancy,the treatment group had 3 pregnancies in the first course,5 pregnancies in the second course and 6 pregnancies in the third course,with a total of 14 pregnancies and a pregnancy rate of 46.7%.In the control group,there was 1 pregnancy in the first course,2 pregnancy in the second course,and 2 pregnancy in the third course,with a total of 5 pregnancies and a pregnancy rate of 16.7%.The difference was statistically significant(P < 0.05),suggesting that the treatment group was superior to the control group in improving pregnancy rate.3.In terms of pregnancy,there were 14 pregnancies in the treatment group,with a pregnancy rate of 46.7%.The total number of pregnancies in the control group was 5,and the pregnancy rate was 16.7%,with statistically significant difference(P < 0.05),suggesting that the therapeutic effect of the treatment group was better than that of the control group in improving the pregnancy rate.4.In terms of the reduction of TCM symptom scores,there were statistically significant differences between the two groups after treatment and before treatment(P < 0.05).After treatment,there were significant differences between the two groups,with statistical significance(P < 0.05),and the curative effect of the treatment group was significantly better than that of the control group.5.In terms of improving BBT type and HPS,after treatment,the difference between the two groups was statistically significant(P < 0.05).After treatment,there were significant differences between the two groups,with statistical significance(P < 0.05),and the curative effect of the treatment group was better than that of the control group.6.In terms of increasing serum P level in the middle luteal phase,after treatment,the difference between the two groups was statistically significant(P < 0.05).After treatment,there were significant differences between the two groups,with statistical significance(P < 0.05),and the curative effect of the treatment group was better than that of the control group.7.In terms of the increase of mid-luteal endometrial thickness,the difference between the two groups after treatment and before treatment was statistically significant(P < 0.05).After treatment,there were significant differences between the two groups,with statistical significance(P < 0.05),and the curative effect of the treatment group was better than that of the control group.8.During medication,dizziness occurred in 1 patient,fatigue in 2 patients and constipation in 1 patient in the control group,but the drugs could be continued;No adverse reactions occurred in the treatment group.9.Safety analysis: routine monitoring of blood,urine and feces during the treatment period,normal liver and kidney function,electrocardiogram,and safety of treatment methods in both groups.Conclusion:The application of Chinese medicine to treat kidney deficiency and blood stasis type of luteal insufficiency infertility can improve the pregnancy,reduce the TCM symptom score,increase the serum P level and endometrial thickness in the middle luteal stage,improve the BBT type and HPS,promote the luteal function and improve the pregnancy rate.