Clinical Observation On Treatment Of Hypertension With Phlegm-dampness Type By Dizziness Decoction

Objective To observe the clinical efficacy and safety of “Dizziness Decoction” in hypertensive patients with the syndrome of excessive phlegm-dampness in Traditional Chinese Medical syndrome scores,clinical single symptom scores,ambulatory blood pressure,LDL-C and UACR.Methods 126 cases of hypertensive patients with excessive phlegm-dampness were included.However,in the course of clinical observation,due to 2 cases of shedding and 4 cases of rejection,there were 120 patients who finally completed the treatment,including 60 in the observation group and 60 in the control group.The control group was treated with oral valsartan amlodipine tablets(I).If blood pressure failed to reach the target of blood pressure,diuretics were combined when necessary.The observation group was given “Dizziness Decoction” on the basis of the control group.The two groups were treated for 4 weeks,the improvement of Traditional Chinese Medical syndrome scores,clinical single symptom scores,ambulatory blood pressure,LDL-C,UACR and so on were compared.Results(1)Comparison of Baseline: The age,sex,family history of early cardiovascular disease,smoking history,drinking history,blood pressure,Traditional Chinese Medical syndrome score,LDL-C and UACR were compared between the two groups before treatment,which were all comparable(P>0.05).(2)Comparison of curative effect of Traditional Chinese Medical syndromes: The total effective rate was 80% in the control group and 98.3% in the observation group(P<0.05).The integral of Traditional Chinese Medical syndromes in the observation group was significantly better than that in the control group after treatment,and the difference was statistically significant(P<0.05).(3)Comparison of clinical single symptom scores: After treatment,the scores of each clinical single symptom in both groups were lower than before(P<0.05).There was no significant difference in headache,chest tightness and palpitation after treatment between the two groups(P>0.05).After treatment,the scores of clinical single symptom such as dizziness,head heavy as if wrapped up,vomiting sputum and saliva,tastelessness,insomnia and diet reduction in the observation group were significantly better than those in the control group(P<0.05).(4)Comparison of ambulatory blood pressure: The 24 h SBP,pulse pressure,blood pressure load were significantly lower in the two groups after treatment(P<0.05).There was no significant difference in circadian rhythm between the control group and before treatment(P>0.05),while there was significant difference in circadian rhythm between the observation group and before treatment(P<0.05).The 24 h SBP,pulse pressure,blood pressure load and circadian rhythm of the observation group were significantly better than those of the control group after treatment,and the difference was statistically significant(P<0.05).There was no significant difference in 24 h DBP between the two groups after treatment(P>0.05).(5)Comparison of LDL-C: After treatment,LDL-C in the observation group were signifi-cantly better than those in the control group,and the difference was statistically significant(P < 0.05).There was no significant difference in LDL-C between the control group before and after treatment(P>0.05).(6)Comparison of UACR: The UACR was significantly better in the observation group than in the control group,and the difference was statistically significant(P<0.05).(7)Comparison of safety: No allergic reaction,adverse reactions related to experimental drugs,and no change of condition were found in the two groups during the treatment.Conclusion “Dizziness Decoction” has good clinical efficacy and safety for hypertensive patients with the syndrome of excessive phlegm-dampness.It can effectively improve Traditional Chinese Medical syndrome scores,clinical single symptom scores,blood pressure levels,adjust blood pressure circadian rhythm,and reduce LDL-C and UACR.It has high clinical application value.