| Objective:This study aims to explore the clinical efficacy of removing dampness and resolving turbidity in the treatment of hypertension accompanied by hyperuricemia and provide a new thought for Traditional Chinese Medicine treatment.Methods:We selected patients who received treatment in January 2020-December 2021 in the first affiliated hospital of Heilongjiang university of traditional Chinese medicine cardiovascular clinic of four department and was diagnosed as mild to moderate(Grade 1-2)hypertension(phlegm-dampness type)accompanied with hyperuricemia.Sixty patients who met the criteria were randomly divided into control group and treatment group,30 cases in each group.Both groups were treated with lifestyle improvement and losartan potassium.The treatment group was additionally treated with method of removing dampness and resolving turbidity,the course of treatment was 4 weeks.The changes of blood pressure,blood uric acid and other indicators before and after treatment were be recorded,and TCM syndrome scores were evaluated according to clinical symptoms.The quality of life of patients was evaluated by Duchenne’s Hypertension quality of life table and the differences between the two groups were compared finally.IBM SPSS 24.0 software was used for data statistics and analysis.Results:1.Changes in blood pressure:After 4 weeks of treatment,the antihypertensive effect of the treatment group was more obvious,compared with the control group,the difference was statistically significant(P <0.05).The total effective rate of hypertension treatment in the treatment group was 93.3%,and the total treatment rate in the control group was 76.6%.The effect of the treatment group was significantly higher than that of the control group.The difference was statistically significant(P < 0.05).2.Changes in blood uric acid:After 2 weeks of treatment,the level of blood uric acid in patients decreased,and after 4weeks of treatment,the level of blood uric acid in the treatment group was significantly lower than that in the control group,with statistical significance(P < 0.05).The total effective rate was 86.7% in the treatment group and 63.3% in the control group,and the difference was statistically significant(P < 0.05).3.The Chinese medicine symptom integral:After 4 weeks of treatment,patients with each individual symptom scores were compared with the previous fall,compared with the control group,treatment group of dizziness,head,such as wrapping,vomit saliva sputum,insomnia,and fewer symptoms improved more obviously tastelessness,the differences were statistically significant(P < 0.05),two groups of patients with TCM syndrome total points are reduced from the previous,but the treatment group decreased more obvious.The total effective rate was 66.7% in the control group and90.0% in the treatment group,and the difference was statistically significant(P < 0.05).4.Safety and quality of life evaluation:There were no abnormal changes in vital signs,hematuria and stool routine,liver and kidney function,and no adverse reactions during the study.After 4 weeks of treatment,the quality of life scores of patients in both groups increased,compared with the control group,the quality of life scores of patients in the treatment group increased more significantly,the difference was statistically significant(P < 0.05).Conclusion:1.Methods of removing dampness and resolving turbidity can effectively reduce blood pressure and uric acid level of patients with mild to moderate(grade 1-2)hypertension(excessive phlegm-dampness syndrome)accompanied by hyperuricemia;2.Methods of removing dampness and resolving turbidity can reduce the TCM syndrome score of patients with mild to moderate(grade 1-2)hypertension(excessive phlegm-dampness syndrome)accompanied by hyperuricemia,and effectively relieve clinical symptoms;3.Methods of removing dampness and resolving turbidity is safe and reliable to treat patients with mild to moderate(grade 1-2)hypertension(excessive phlegm-dampness syndrome)accompanied by hyperuricemia,without obvious adverse reactions,and improve the quality of life of patients. |
