Analysis Of Brain Regulation Effects For Autism

Autism spectrum disorder(ASD)is a developmental disorder caused by neurological disorders,it is often accompanied by three major symptoms: language disability,social disorders,and repetitive stereotyped behaviors.Until now,the pathogenesis of autism is still unclear,it cannot be cured and will accompany the patient for a lifetime..As the incidence of autistic children continues to rise,autism is getting more and more attention from the society.The purpose of this paper is to study the differences of brain function in children with autism,and to explore the brain regions sensitive to transcranial direct current(tDCS)intervention in autistic patients.It is expected that tDCS can better improve the brain function of autistic children.In this study,25 normal children and 25 autistic children were selected as subjects to collect and analyze resting EEG signals of two groups of subjects.EEG signals were analyzed from two aspects: brain region correlation and EEG signal feature values.Brain region correlation analysis firstly used the wavelet decomposition method to extract the four rhythm waves of the 16-channel EEG signals of the two groups of subjects in the frontal,temporal,apical and occipital regions,and then calculated the synchronization characteristics between two channels of four rhythm waves.EEG signal eigenvalue analysis firstly analyzed the EEG difference between children with autism and normal children by comparing the complexity and sample entropy eigenvalues of EEG signals between the two groups.Then,20 children with autism were selected for a five-week,ten-time tDCS.In order to explore areas of the brain that are sensitive to tDCS in autistic patients,the changes of EEG eigenvalues of six groups of EEG signals collected during ten interventions were analyzed in frontal,parietal,temporal and occipital regions four brain regions to explore the sensitive brain regions of autistic patients with tDCS.The results of the analysis showed that the correlation of brain regions in children with autism was lower than that in normal children under the four rhythm waves of beta,alpha,theta and delta,and the EEG signal complexity and sample entropy in the whole brain region had diversity with those in normal children.Twenty children with autism who participated in tDCS had a decrease in ABC behavior scale scores,improved language action ability,and increased brain-related correlation under the four rhythm waves after ten stimulations.This indicates that tDCS is an effective means to assist patients with autism.After intervention,the subject's EEG signal complexity and sample entropy characteristic values in the frontal,top and anterior temporal regions showed an obvious change.These three regions were sensitive to tDCS intervention in autistic patients.There were no significant changes in the characteristics of EEG signals in the brain,occipital and temporal regions.These two regions were non-sensitive brain regions.