Investigation On The Biomolecules And Chinese Medicine Constitution Of Perimenopausal Women

Objective Analyzing the Evolution of serum follicle stimulating hormone?FSH?,serum cholesterol?TC?,serum hemoglobin?HB?and body mass index?BMI?in 500 women aged 40⁶0 years old.Analysis,scoring and judgment of TCM constitution in another 500 women aged 40⁶0 years old.Research about the related indicators of the physical evolution of women in special life stages before and after the menopause from different angles.Methods 1.Research method?1?According to the method of multi-stage cluster random sampling,Analysis of serum follicle stimulating hormone?FSH?,serum cholesterol?TC?,serum hemoglobin?HB?and body mass index?BMI?in 500 women aged 40⁶0 years and 150 women of reproductive age from December 1,2016 to July 30,2017.Serum FSH?detected by the American Beckman company providing hormone kit?.Serum TC,serum HB?detected by American LX20 Beckman automatic chemiluminescence analyzer?.BMI?measured by the MDSIN Maison quality human body fat meter TBF-418B?TANITA?to measure the height,weight and BMI of medical examiners?.?2?The analysis and scoring of the"Classification and Judgment of TCM Constitution"published by the Chinese Medicine Association of China April 9,2009for analysis,scoring and judgment in 500 women aged 40⁶0 years from November1,2016—June 30,2017.?3?Observing separately the changes of Serum indicators and TCM constitution during 20 years,10 years,and 5 years.2.Grouping method according to the objective laws of evidence-based medicine,himself through the statistical analysis,the growth period of 20 years of 40⁶0 years old women and women FSH,TC,HB,BMI level differences statistically significant?P<0.05?,in order to further explore their changes of frequency and time limit,we have conducted a series of 10 years group and 5 years group,in 10 years group,two groups of 40⁶0 years old women and the growth of FSH,TC,HB,BMI level differences statistically significant?P<0.05?;In the 5-year group,there were statistically significant differences in FSH,TC,HB,and BMI between the four groups of women aged 40 to 60 years old who underwent physical examination and women of reproductive age?P<0.05?,which were smaller than the 5-year group and had no statistically significant differences?P>0.05?.TCM constitution group is divided into groups according to the grouping method of biomolecule group and discusses the process of human life evolution from different angles.?1?20 years group Biomolecular group:serum FSH,serum TC,serum HB and BMI of 500 women aged 40⁶0 years in group A₂₀.TCM constitution group:B₂₀ group included 500 women aged 40⁶0 years.?2?10 years group Biomolecular group:serum FSH,serum TC,serum HB and BMI of 229 women aged 40⁵0 years in group A₁₀,and serum FSH,serum TC,serum HB and BMI of 271 women aged 51⁶0 years in group B₁₀.TCM constitution group:206 cases of women aged 40⁵0 in C₁₀0 group and 294cases of women aged 51⁶0 in D₁₀ group.?3?5 years group Biomolecular group:125 cases of serum FSH,serum TC,serum HB and BMI in women aged 40⁴5 years in group A₅,108 cases of serum FSH,serum TC,serum HB and BMI in women aged 46⁵0 years in group B₅,144cases of serum FSH,serum TC,serum HB and BMI in women aged 51⁵5 years in group C₅,123 cases of serum FSH,serum TC,serum HB and BMI in women aged56⁶0 years in group D_5.TCM constitution group:108 cases in E5 group were 40⁴5 years old;99 cases in F₅ group were 46⁵0 years old;149 cases in G₅ group were 51⁵5 years old;144cases in H₅ group were 56⁶0 years old.Results 1.there were statistically significant differences in FSH,TC,HB and BMI between women aged 40-60 and women of reproductive age in 20 years?P<0.05?.2.There were statistically significant differences in FSH,HB and BMI between group A₁₀0 and women of reproductive age?P<0.05?,while there was no statistically significant difference in TC level between the two groups?P>0.05?.The differences in FSH,TC,HB and BMI between B10 group and women of reproductive age were statistically significant?P<0.05?.There were statistically significant differences in FSH,TC and HB between groups A10 and B10?P<0.05?,and no statistically significant differences in BMI?P>0.05?.During the 10-year period,FSH,TC,HB and BMI of group A10 and group B10 showed a continuous progressive increase with age.3.There were statistically significant differences in FSH,HB and BMI between the A₅ group and women of reproductive age?P<0.05?,but no statistically significant differences with the HB level.There were statistically significant differences in FSH,TC and BMI between B₅ group and women of reproductive age?P<0.05?,but no statistically significant differences between B₅ group and women of reproductive age?P>0.05?.There were statistically significant differences in FSH,TC,HB and BMI between the C5 group and women of reproductive age?P<0.05?.There were statistically significant differences in FSH,TC,HB and BMI between D₅ group and women of reproductive age?P<0.05?.4.Comparison of FSH,TC,HB,and BMI among the four groups:FSH in the 5years group:There was a statistically significant between the high age group and the low age?P<0.05?.TC:TC of the 5 years group showed a continuous progressive upward curve with increasing age,but the angle of increase from the first group to the second group was relatively large,and there was no statistically significant in TC level?P>0.05?.HB:HB in the 5 years group showed a continuous and progressive increase with age.There was Statistically significan between A5 group and B5 group,C5 group and D₅ group?P<0.05?.There was no Statistically significan between C₅ group and B₅group and D₅ group?P>0.05?.BMI:BMI increased progressively with increasing age.There wasStatistically significan between A₅ group and B₅ group,C₅ group and D₅ group?P<0.05?.There was no Statistically significan between C₅ group and B5 group and D₅ group?P>0.05?.5.In 500 women aged 40⁶0 years,the biased constitution accounted for 73.4%?367/500?,and the average quality accounted for 26.6%?133/500?,and there was a Statistically significant?P<0.05?.6.In the first 10 years,the top three in the biased constitution are 19.8%?41/206?of qi deficiency,13.5%?26/206?of yin deficiency,and 10.6%?22/206?of yang deficiency.The three are yin deficiency 27.0%?79/294?,qi deficiency 12.6%?37/294?and yang deficiency 12.6%?37/294?,and moist heat 7.8%?23/294?.There were Statistically significan in yin deficiency and qi deficiency in the first 10 years?P<0.05?.7.In the five years,the biased constitution of the E5,F5,G5,and H5 groups were ranked and ranked according to the weight of the proportion:Group E₅:qi deficiency 17.6%?19/108?,moist heat 15.7%?17/108?,yin deficiency 9%9.3?10/108?.Group F₅:22.2%?22/99?of qi deficiency,18.2 cases?18/99?of yin deficiency,and 12.1%?12/99?of yang deficiency.Group G₅:yin deficiency 28.9%?43/149?,qi deficiency 14.1%?21/149?,yang deficiency 9.4%?14/149?.H₅ group:yin deficiency 25.0%?36/144?,yang deficiency 16.0%?23/144?,blood sputum 11.8%?17/144?.Conclusion 1.Perimenopausal period and the period before and after menopause is an important period when the life prime number of women changes.During this period,FSH,TC,HB and BMI increase continuously due to ovarian function decline and metabolism slowing down.2.The perimenopausal women's TCM constitution is dominated by partial physique.After 40 years old,the proportion of 8 kinds of partial physique can be gradually changed from qi deficiency to yin deficiency.The first 10 years of 40⁶0years old women,C₁₀ group,eccentric qi deficiency is the first place.In the last 10years,the D₁₀0 group was the first in terms of yin deficiency,which was consistent with the 7years life evolution cycle of women before and after the break.