The Observation Of Clinical Men’S Dingchuan Decoction Combined With Seretide Therapy In Deficiency Of Lung And Spleen-qi In Stable Stage Of COPD

Objective:To observe the clinical efficacy and safety of modified Men’s dingchuan Decoction combined with Seretide in the treatment of COPD patients with lung qi deficiency in stable phase,and to provide more basis for clinical treatment of COPD in stable phase.Methods:82 patients with stable COPD were randomly divided into treatment group（41 cases）and control group（41 cases）.The control group was treated with Seretide,and the treatment group was treated with modified Men’s dingchuan Decoction on the basis of seretide.Before and after the treatment,the clinical symptoms,pulmonary function values,quality of life assessment data,exercise tolerance and degree of dyspnea of the two groups were analyzed and the therapeutic effect was determined,and the therapeutic effect of modified Men’s Dingchuan decoction was observed.Results:1.There was no significant difference between the two groups in gender,age,course of disease and pulmonary function grade before treatment（P>0.05）.2.Comparison of the total score of TCM syndromes:after treatment,there was statistical significance between the two groups（P<0.05）.The scores of TCM syndromes in both groups were improved and decreased,and the treatment group was better than the control group.3.the two groups improved in each single integral aspect,indicating that both can improve the syndrome of deficiency of lung and spleen qi.Compared with the control group,the therapeutic effect of the treatment group was better than that of the control group（P<0.05）.4.Pulmonary function comparison:after treatment,FEV₁%and FEV₁/FVC%of the patients in the two groups were compared within the group,P<0.05,indicating that the difference was statistically significant.5.CAT score comparison:after treatment,the cat scores of the two groups were P<0.05,with statistical significance.The CAT scores of the two groups were improved and decreased,and the treatment group was better than the control group,indicating that the improvement of quality of life in the treatment group was better than the control group.6.comparison of six minute walking distance:the comparison between the two groups before and after treatment,P<0.05,with statistical significance.After treatment,the two groups were compared,P<0.05,with statistical significance,and the treatment group was better than the control group.7.The degree of dyspnea in the two groups after treatment was statistically significant（P<0.05）.The scores of dyspnea in both groups were improved and decreased,and the treatment group was better than the control group.8.Efficacy judgment:both groups are effective,but the total effective rate of the control group is lower than that of the treatment group,81.08%of the control group.The improvement of the treatment group is obvious,the total effective rate is 92.10%.Through the rank sum test,the result is P<0.05,the difference is statistically significant,and the treatment group is better than the control group in general.9.There was no abnormal change in the safety indexes of the two groups before and after treatment,and no obvious adverse reactions occurred.Conclusion:The combination of modified Men’s dingchuan Decoction and Seretide can effectively alleviate the clinical symptoms of COPD patients in stable stage,improve the pulmonary function of patients,to a certain extent,improve the sports endurance,quality of life and improve the degree of dyspnea of patients,without obvious adverse reactions,clinical application is safe and effective,which is worthy of clinical promotion.