| Objective: Through a retrospective study of patients with primary liver cancer(PHC),the distribution pattern of TCM syndromes in PHC is discussed,and the correlation between the TCM syndromes and laboratory indicators is analyzed,which provides a reference for the differentiation and treatment of TCM and standardized diagnosis and treatment of PHC.Methods: Collect and organize medical records of 462 patients diagnosed with PHC from June 2014 to December 2018,including basic information,previous medical history,main symptoms,four diagnosis conditions,and laboratory indicators at admission,Complications and other information.SPSS 22.0 software was used to sort and analyze the collected data,and tests such as normal distribution test,chi-square test,rank sum test were used to find the statistical significance and correlation of data between groups.Results:1.Among the 462 patients with PHC,327 were male and 135 were female.The male-to-female incidence ratio was 2.42: 1.The incidence of PHC was statistically different(P <0.05).The incidence of male patients was higher than that of female patients.The average of male patients was 1.The age of onset was(60.76 ± 10.59 years),and the average age of onset of female patients was(64.42 ± 10.12 years).There was a significant difference in the age of onset between male and female patients(P <0.05).The age of female patients was higher than that of male patients.2.The distribution of the top 20 clinical symptoms is as follows: 346 cases of flank fullness(74.89%),322 cases of fatigue(69.70%),287 cases of dry mouth(62.12%),and 246 cases of appetite(53.25%)243 cases of yellow urine(52.60%),236 cases of liver discomfort(51.08%),234 cases of rib pain(50.65%),226 cases of abdominal distension(48.92%),219 cases of sputum(47.40%)),206 cases of mouth pain(44.59%),188 cases of diarrhea(40.69%),184 cases of painful back pain(39.83%),176 cases of sleep difference(38.10%),170 cases of yellow dye(accounting for 36.80%),165 cases of fecal diarrhea(35.71%),153 cases of good and too much interest(33.12%),152 cases of weight loss(32.90%),150 cases of abdominal pain(32.47%),and 150 cases of irritability and irritability(accounting for 36.80%)32.47%),149 cases of dysuria(32.25%).3.Common clinical complications: 214 cases of hypoproteinemia(46.32%),200 cases of electrolyte metabolism disorder(43.29%),195 cases of peritoneal effusion(42.21%),39 cases of hepatic encephalopathy(8.44%),and upper gastrointestinal bleeding 27 Cases(5.84%),27 cases(5.84%)of infection,12 cases of hepatorenal syndrome(2.60%),10 cases of chronic liver failure(2.16%),8 cases of splenomegaly(1.73%),8 cases of metabolic acidosis(1.73%).There is no correlation between TCM syndrome types and complications(P> 0.05)4.Distribution of TCM syndrome types: The most frequent patients are blood stasis syndrome(200 cases,43.29%),and the others are damp heat syndrome(100 cases,21.65%),and liver stagnation and qi stagnation syndrome(84 cases,18.18).%),Liver and kidney yin deficiency syndrome(35 cases,accounting for 7.58%),spleen deficiency and dampness syndrome(25 cases,accounting for 5.41%),phlegm condensation heat syndrome(18 cases,accounting for 3.89%);There were differences between different ages of onset(P <0.05).Among them,the average age of onset of damp heat syndrome was the youngest(58.26 ± 8.51 years),and the average age of onset of liver and kidney yin deficiency was the oldest(67.66 ± 8.80 years).5.TCM syndrome types and length of stay: There was no statistical difference in the number of days of hospitalization among TCM syndrome types,patient age,and patient gender(P> 0.05).6.Child-pugh classification of liver function: 29 cases of grade A(71.22%),103 cases of grade B(22.29%),30 cases of grade C(6.49%),the difference between TCM syndrome type and Child-pugh grade There were statistical differences(P> 0.05).7.TCM syndrome types and laboratory examinations: There was a correlation between TBIL,DBIL,IBIL,ALT,AST,ALB,TBA,PT,RBC,WBC and TCM syndrome types(P <0.05).8.Season of onset: The incidence of patients is mostly in summer(129 cases,accounting for 27.92%),spring(116 cases,accounting for 25.11%)and autumn(115 cases,accounting for 24.89%).Cases,accounting for 22.08%).Conclusion:1.The incidence of PHC patients in the affiliated hospital of Changchun University of Traditional Chinese Medicine is different from different genders and ages;the incidence of male patients is greater than that of female patients,and the age of female patients is higher than that of male patients.2.The incidence of different TCM syndrome types is different.Patients with blood stasis syndrome are the most common,and patients with phlegm condensation and heat poisoning syndrome are the least.There is a correlation between the distribution of syndrome types and the age of onset.The average age of onset of yin deficiency syndrome is the largest.3.In laboratory tests,the results of TBIL,DBIL,IBIL,ALT,AST,TBA,WBC,RBC and other laboratory indicators were significantly higher than those of other syndromes;the results of ALB Medium was significantly lower than other syndromes;blood stasis syndrome was significantly longer in PT than other syndromes.Compared with other syndrome types,the phlegm coagulation heat toxicity syndrome has more severe damage to liver cells,worse liver synthesis function,and blood stasis syndrome has worse liver coagulation function than other syndrome types. |
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