Clinical Observation Of Pingchuan Zhixiao Decoction In The Treatment Of Chronic Persistence Of Severe Asthma (Yang Deficiency And Phlegm Stasis Syndrome)

Objective:To observe the efficacy and safety of Pingchuan Zhixiao decoction in the treatment of chronic duration of severe asthma（Yang deficiency and phlegm stasis syndrome）,to provide basis and reference for the treatment of severe asthma with TCM,and to provide reference scheme and objective basis for clinical treatment of SA.Methods:Sixty-eight patients who met the inclusion criteria were randomly divided into treatment group（n=34）and control group（n=34）.The patients in the control group were treated with western medicine（inhaled salmeterol fluticasone powder inhaler+tiotropium bromide powder inhaler+salbutamol sulfate aerosol as needed）,and the patients in the treatment group were treated with Pingchuan Zhixiao decoction on the basis of treatment in the control group.The course of treatment was 6 weeks.After treatment,the plasma（IL-4and IFN-γ）,pulmonary function,exhaled nitric oxide,asthma control test score,TCM syndrome score and drug safety index of the two groups were compared and evaluated,and the data were statistically analyzed by statistical software SPSS25.0.Result:1.General data analysis:Excluding the excluded and shedding cases,60 cases completed the study,including 30 cases in the treatment group and 30 cases in the control group.There was no significant difference in age,sex and course of disease between the two groups（P>0.05）,and there was no significant difference between the two groups in terms of age,sex and course of disease（P>0.05）.2.The curative effect of TCM syndrome:There was significant difference between the two groups after treatment（P<0.05）.The total effective rate of the treatment group was higher than that of the control group（83.33%>60.00%）.3.TCM syndrome scores:TCM syndrome scores:the total scores of patients in the two groups after treatment were significantly lower than those before treatment,and the difference was statistically significant（P<0.01）.After treatment,the total score of the treatment group was lower than that of the control group,and the difference was statistically significant（P<0.01）.Comparison of the scores of main symptoms（shortness of breath,chest tightness,shortness of breath,cough,expectoration）:the TCM syndrome scores of symptoms such as shortness of breath,chest tightness and shortness of breath,cough and expectoration in the two groups were significantly lower than those before treatment（P<0.05）.After treatment,the scores in the treatment group were lower than those in the control group,and the differences were statistically significant（P<0.05）.Comparison of scores of secondary symptoms（fatigue,chills,cold limbs,bruise on lips,bruise,or lack of food）:the scores of all TCM syndromes in the treatment group after treatment were lower than before treatment,the differences were statistically significant（P<0.01）;In addition to the difference in the control group before and after the treatment of Shenpi fatigue,there was a statistically significant difference（P<0.05）,and there was no statistically significant difference in the scores of other TCM syndromes before and after the treatment（P>0.05）.At the same time,the points of the treatment group after treatment were lower than those of the control group,and the differences were statistically significant（P<0.05）.4.Pulmonary function:The levels of FEV₁,FEV₁%,FEV₁/FVC%and PEF in the two groups after treatment were significantly higher than those before treatment（P<0.01）.At the same time,the FEV₁,FEV₁%and FEV₁/FVC%in the treatment group were significantly higher than those in the control group,and the improvement of PEF in the treatment group was higher than that in the control group,but there was no significant difference between the two groups（P>0.05）.5.Exhaled nitric oxide:The FeNO value of the two groups after treatment was significantly lower than that before treatment,and the FeNO value of the treatment group after treatment was significantly lower than that of the control group（P<0.05）.6.Plasma IL-4 and INF-γ:After treatment,the plasma IL-4 of the two groups was lower than that before treatment,and the plasma IFN-γwas higher than that before treatment,and the difference was statistically significant（P<0.01）.At the same time,the plasma IL-4of the treatment group was lower than that of the control group after treatment,and the plasma IFN-γof the treatment group was higher than that of the control group.7.Safety index:There was no obvious abnormality in liver and kidney function between the two groups,and there was no significant difference between the two groups（P>0.05）,indicating that the drug was safe.Conclusion:1.On the basis of maintaining standard treatment,the treatment group was treated with Pingchuan Zhixue decoction,which has the effects of warming yang and replenishing qi,promoting blood circulation and removing phlegm,which can improve the symptoms of asthma,such as shortness of breath,shortness of breath,cough,expectoration and so on.it is better than the control group in reducing the recurrence and aggravation of asthma,thus achieving the purpose of improving patients’lung function,reducing pulmonary inflammation and improving patients’quality of life,which is worthy of clinical application.2.This prescription has strict compatibility,no liver and kidney injury and toxic side effects,is safe and reliable,and is worth popularizing and applying in clinic.