Study On Risk Factors Of Cerebral Microbleed In Patients With Non-disabling Ischemic Cerebrovascular Events

Objective(s):To investigate the relationship between risk factors and related genes in cerebral micro-bleeds(CMBs)in patients with non-disabling ischemic cerebrovascular events.Methods:Magnetic Resonance Imaging was performed in 159 patients with non-disabling ischemic cerebrovascular events,which included susceptibility-weighted imaging.All patients receives cranial magnetic resonance imaging at the first week.Genetic Testing and other biochemical parameters were measured on the next day of admission.Results:1.Of225 patients,106(47.1%)patients were the detected of CMBs.2.History of hypertension,diabetes,atherosclerosis,stroke or TIA history,using blood pressure medication,antiplatelet drugs,statins,and higher blood pressure levels,cerebral white matter Fazekas score is higher,were significantly associated with the presence of CMBs.3.Through logistic regression analysis,diabetes(OR=OR=2.050,95%CI=0.996-4.217,P=0.051),cerebral white matter Fazekas score is higher(OR=2.010,95%CI=1.641?2.463,P<0.001)were included in the model,it indicates that the history of diabetes mellitus and high Fazekas score are independent risk factors for cerebral microhemorrhage.Multiple linear regression analysis showed that the number of CMBs was positively correlated with the scores of white matter Fazekas(r=0.514,p<0.001),statins(r=0.247,p<0.023)and diastolic blood pressure(r=0.124,p<0.040).4.PRNP and CST3 genes were detected in 16 patients with CMBs,and the results of 1 patient indicated the presence of gene mutation,while no significant abnormalities were found in 15 patients.Conclusion(s):1.The incidence of cerebral microhemorrhage is high in patients with non-disabling ischemic cerebrovascular events.2.Higher blood pressure levels,diabetes,cerebral white matter Fazekas score is higher were the independent risk factor for CMBs in patients with stroke.3.White matter Fazekas score,statin use,and high diastolic blood pressure were independently and positively correlated with the number of CMBs,suggesting that these three factors could provide a basis for predicting the number of CMBs4.There may be correlation between CMBs and PRNP and CST3 genes.