The Study On The Correlation Between Serum Vaspin Level And Non-disabling Ischemic Cerebrovascular Disease

Objective To investigate the level of Vaspin with Non-Disabling Ischemic Cerebrovascular Events and its clinical significance.Methods 95 patients with non-disabling ischemic cerebrovascular events(NICE)diagnosed and treated in our department of neurology from December 1,2016 to July 31,2017 were selected as the NICE group.According to ADA guidelines for diabetes management,the NICE components were: 48 cases with NICE non-glycometabolism abnormal(AGM)group(group A)and 47 cases with NICE combined AGM group(group B).45 cases of AGM patients who were diagnosed in the Department of Endocrinology and Metabolism of our hospital during the same period were simple AGM group(group C);50 patients undergoing physical examination in our hospital had neither abnormal glucose metabolism nor cerebral infarction as the control group(group D).All subjects were recorded general information on gender,age,height,weight,history of hypertension,and smoking history after admission.The following morning,fasting blood was collected for biochemical indicators such as blood glucose,blood lipids,and Hb A1 c,and the subject's fasting was taken.Venous blood 5 m L,using human VASPIN enzyme-linked immunosorbent assay kit from Wuhan Elabscience to determine the serum Vaspin concentration in each group.Results(1)There was no significant difference in the age,sex,and prevalence rate of hypertension among the four groups;the smoking rate in the NICE group was higher than that in the AGM group and the physical examination control group,and the difference was statistically significant(P<0.05).(2)In the composition of ischemic events of the NICE group,in the non-AGM group,the proportion of TIA and rapid symptom relief without significant disability was higher,while in the combined AGM group,the proportion of mild stroke was higher.(3)According to stratification of carotid ultrasound,in the non-AGM of the NICE group,the ratio of carotid intima roughness was higher,while the proportion of carotid plaque formation was higher in the conbined AGM,And the difference is statistically significant(P<0.05).(4)Among the four groups,The blood glucose-related indexes,such as FBG,FINS,Hb A1 c,BMI,and HOMA-IR,were higher in the presence of AGM groups than those without AGM groups(P<0.05).The concentrations of TG in NICE without AGM group,NICE with AGM group and AGM alone group were significantly higher than those in physical examination control group(P<0.05),but there were no significant difference among the three groups.The concentrations of TC and LDL in NICE without AGM group and NICE combined AGM group were higher than those in simple AGM group and physical examination control group,and the difference was statistically significant(P<0.05),but there were no significant difference between the two groups.The concentration of HDL in NICE without AGM group and NICE combined with AGM group was lower than that in physical examination control group,and the difference was statistically significant(P=0.01).There was no significant difference between the other groups.In the acute phase of NICE,serum Vaspin levels decreased,and the relationship between the four groups was simple AGM group> physical examination control group> NICE combined AGM group> NICE non-AGM group,and the difference was statistically significant(P<0.05).(5)Vaspin was positively correlated with the ralated indicators of blood glucose metabolism such as FBG,FINS,BMI,HOMA-IR,Hb A1c(P<0.05),and had the strongest correlation with the indicator of HOMA-IR(r=0.321).(6)In the NICE combined AGM group,there was no significant difference between serum Vaspin concentration and insulin resistance index(HOMA-IR)in both pre-diabetes and diabetic stages(P>0.05).(7)In the NICE without AGM group,the serum Vaspin concentration in carotid artery multiple plaque group,carotid artery stenosis and occlusion group were significantly lower than those in carotid artery rough group,and the difference was statistically significant(P<0.05).(8)After adjusting for age,sex,and other confounding factors,the analysis showed that TC,LDL-C and smoking were risk factors for NICE occurrence.The OR values were 5.126(95% CI: 2.814-9.337),2.557(95% CI:1.471-4.444)and 3.150(95% CI: 1.354-7.331);Serum Vaspin may be a protective factor for NICE,the OR value was 0.880(95% CI: 0.840-0.964),which means that the risk of NICE was reduced by 0.880 times for each increment of serum Vaspin.Conclusion(1)The decrease of serum Vaspin level in the acute phase of NICE patients,Vaspin may be a protective factor in the occurrence and development of NICE,which may be a new biological marker for the prediction of NICE.(2)Serum Vaspin level was negatively correlated with the degree of carotid atherosclerosis.The decrease of Vaspin level promoted the progression of atherosclerosis.(3)The level of serum Vaspin is compensatoryly increased in patients with abnormal blood glucose metabolism,and insulin resistance already exists in prediabetes..